Technology Process of 3-amino-1-benzylindolin-2-one hydrochloride
There total 5 articles about 3-amino-1-benzylindolin-2-one hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 20 °C / 760.05 Torr
2: hydrogenchloride / methanol
With
hydrogenchloride; palladium 10% on activated carbon; hydrogen;
In
methanol;
DOI:10.1021/ol200724q
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydroxylamine hydrochloride / water / 0.5 h / Reflux
1.2: 0.5 h / Reflux
2.1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 20 °C / 760.05 Torr
With
palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen;
In
methanol; water;
DOI:10.1016/j.tet.2018.11.016
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 20 °C
2.1: hydroxylamine hydrochloride / water / 0.5 h / Reflux
2.2: 0.5 h / Reflux
3.1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 20 °C / 760.05 Torr
With
palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; sodium hydride;
In
methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2018.11.016
