METHYL-1-BENZYL-4-METHYL-PYRROLIDINE-3-CARBOXYLATE

Base Information

• Chemical Name: METHYL-1-BENZYL-4-METHYL-PYRROLIDINE-3-CARBOXYLATE
• CAS No.: 885958-67-8
• Molecular Formula: C14H19NO2
• Molecular Weight: 233.31
• Hs Code.: 2933990090
• Mol file: 885958-67-8.mol

Synonyms:Methyl1-benzyl-4-methylpyrrolidine-3-carboxylate;

Chemical Property of METHYL-1-BENZYL-4-METHYL-PYRROLIDINE-3-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0.00101mmHg at 25°C
• Refractive Index: 1.532
• Boiling Point: 302.2 °C at 760 mmHg
• Flash Point: 103.9 °C
• PSA: 29.54000
• Density: 1.081 g/cm³
• LogP: 1.86540
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Methyl1-benzyl-4-methylpyrrolidine-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL-1-BENZYL-4-METHYL-PYRROLIDINE-3-CARBOXYLATE

There total 2 articles about METHYL-1-BENZYL-4-METHYL-PYRROLIDINE-3-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.6%

crotonic acid methyl ester (623-43-8) + N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine (93102-05-7) → methyl 1-benzyl-4-methylpyrrolidine-3-carboxylate (885958-67-8)

Guidance literature:

crotonic acid methyl ester; N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;

With sodium carbonate; In dichloromethane; water;

Reference yield:

N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine (93102-05-7) + ethyl (E)-crotonate (623-70-1) → methyl 1-benzyl-4-methylpyrrolidine-3-carboxylate (885958-67-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 28 ℃; for 16h;

Reference yield: 100.0%

methyl 1-benzyl-4-methylpyrrolidine-3-carboxylate (885958-67-8) → (3RS,4RS)-1-benzyl-4-methyl-pyrrolidine-3-carboxylic acid (885958-71-4)

Guidance literature:

With hydrogenchloride; water; at 70 - 80 ℃;

upstream raw materials:

crotonic acid methyl ester

N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine

ethyl (E)-crotonate

Downstream raw materials:

(3RS,4RS)-1-benzyl-4-methyl-pyrrolidine-3-carboxylic acid

Refernces

• 1、 -. "BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS". Page/Page column 37. . Retrieved 2009/07/17.