1-METHYL-1H-PYRAZOLE-3-SULFONYL CHLORIDE

Base Information

• Chemical Name: 1-METHYL-1H-PYRAZOLE-3-SULFONYL CHLORIDE
• CAS No.: 89501-90-6
• Molecular Formula: C4H5ClN2O2S
• Molecular Weight: 180.615
• Hs Code.: 2933199090
• Mol file: 89501-90-6.mol

Synonyms:1-Methyl-1H-pyrazole-3-sulfonylchloride;1-Methylpyrazole-3-sulfonyl chloride;

Chemical Property of 1-METHYL-1H-PYRAZOLE-3-SULFONYL CHLORIDE

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.622
• Boiling Point: 295.672 °C at 760 mmHg
• PKA: -3.70±0.10(Predicted)
• Flash Point: 132.618 °C
• PSA: 60.34000
• Density: 1.605 g/cm³
• LogP: 1.42840
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Methyl-1H-pyrazole-3-sulfonyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Methyl-1H-pyrazole-3-sulfonyl Chloride is a reagent used in the synthesis of glucokinase activators which potently activate glucokinase in enzyme and cell assays.

Technology Process of 1-METHYL-1H-PYRAZOLE-3-SULFONYL CHLORIDE

There total 3 articles about 1-METHYL-1H-PYRAZOLE-3-SULFONYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

1-methyl-1H-pyrazol-3-amine hydrochloric acid → 1-methyl-1H-pyrazole-3-benzenesulfonyl chloride (89501-90-6)

Guidance literature:

1-methyl-1H-pyrazol-3-amine hydrochloric acid; With hydrogenchloride; sodium nitrite; In water; acetonitrile; at 0 ℃; for 0.75h;

With copper(II) chloride dihydrate; sulfur dioxide; acetic acid; copper(l) chloride; In water; acetonitrile; at 0 - 10 ℃;

Reference yield: 32.0%

methyl-1 amino-3 pyrazole (1904-31-0) → 1-methyl-1H-pyrazole-3-benzenesulfonyl chloride (89501-90-6)

Guidance literature:

methyl-1 amino-3 pyrazole; With hydrogenchloride; sodium nitrite; In water; acetonitrile; at 0 ℃; for 0.666667h;

With sulfur dioxide; acetic acid; copper(l) chloride; copper dichloride; In water; acetonitrile; at 0 ℃; for 1.33333h; under 775.743 Torr;

Reference yield:

methyl-1 amino-3 pyrazole (1904-31-0) → 1-methyl-1H-pyrazole-3-sulfonamide (88398-97-4) + 1-methyl-1H-pyrazole-3-benzenesulfonyl chloride (89501-90-6)

Guidance literature:

With hydrogenchloride; acetic acid; sodium nitrite; copper(l) chloride; In water;

upstream raw materials:

methyl-1 amino-3 pyrazole

Downstream raw materials:

1-methyl-1H-pyrazole-3-sulfonic acid (4-chloro-benzyl)-(1-oxo-1,2,3,4-tetrahydro-isoquinolin-7-yl)-amide

1-methyl-1H-pyrazole-3-sulfonic acid benzyl-(1-oxo-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide

N-{3-[7-(1-{3-(Cyanomethyl)-1-[(1-methyl-1H-pyrazol-3-yl)sulfonyl]azetidin-3-yl}-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]phenyl}-N'-(2,2,2-trifluoroethyl)urea

6-[benzyl-(1-methyl-1H-pyrazole-3-sulfonyl)-amino]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Refernces

• 1、 -. "SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME". Page/Page column 89; 102. . Retrieved 2016/09/15.