cyclohexyl carbamoylmethyl carbamic acid benzyl ester

Base Information

• Chemical Name: cyclohexyl carbamoylmethyl carbamic acid benzyl ester
• CAS No.: 3496-41-1
• Molecular Formula: C₁₆H₂₂N₂O₃
• Molecular Weight: 290.362
• Mol file: 3496-41-1.mol

Synonyms:cyclohexyl carbamoylmethyl carbamic acid benzyl ester

Chemical Property of cyclohexyl carbamoylmethyl carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of cyclohexyl carbamoylmethyl carbamic acid benzyl ester

There total 9 articles about cyclohexyl carbamoylmethyl carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

cyclohexylamine (108-91-8,157973-60-9) + N-(Benzyloxycarbonyl)glycine (1138-80-3) → cyclohexyl carbamoylmethyl carbamic acid benzyl ester (3496-41-1)

Guidance literature:

N-(Benzyloxycarbonyl)glycine; With ethyl 2-(tert-butoxycarbonyloxyimino)-2-cyanoacetate; N-ethyl-N,N-diisopropylamine; In ethyl acetate; at 0 - 5 ℃; for 1h;

cyclohexylamine; In ethyl acetate; at 0 - 5 ℃; for 2h;

DOI:10.1002/adsc.201200645

Reference yield: 80.0%

benzyl N-benzyloxycarbonylglycinate (5513-38-2) + aniline (62-53-3) → cyclohexyl carbamoylmethyl carbamic acid benzyl ester (3496-41-1)

Guidance literature:

at 40 ℃; for 5h; in incubator;

DOI:10.1016/j.tetlet.2011.03.039

Reference yield: 41.0%

Cbz-Gly-ONSuc (2899-60-7) + cyclohexylamine (108-91-8,157973-60-9) → cyclohexyl carbamoylmethyl carbamic acid benzyl ester (3496-41-1)

Guidance literature:

With triethylamine; In dichloromethane; Ambient temperature;

DOI:10.1021/jm970086f

upstream raw materials:

cyclohexylamine

N-(Benzyloxycarbonyl)glycine

(2-Benzoylaminooxy-2-oxo-ethyl)-carbamic acid benzyl ester

Cbz-Gly-ONSuc

Downstream raw materials:

2-amino-N-cyclohexylacetamide

2-(3-cyanophenylsulfonamido)-N-cyclohexylacetamide

3-(N-(2-cyclohexylamino-2-oxoethyl)-N-sulfamoyl)benzamidine

3-(N-(2-cyclohexylamino-2-oxoethyl)-N-sulfamoyl)benzamidinium trifluoroacetate

Refernces

• 1、 Dosa, Stefan,Stirnberg, Marit,Luelsdorff, Verena,Haeussler, Daniela,Maurer, Eva,Guetschow, Michael. "Active site mapping of trypsin, thrombin and matriptase-2 by sulfamoyl benzamidines". . p. 6489 - 6505,17. Retrieved 2012/12/11.
• 2、 Geurts, Muriel,Poupaert, Jacques H.,Scriba, Gerhard K. E.,Lambert, Didier M.. "N-(benzyloxycarbonyl)glycine esters and amides as new anticonvulsants". . p. 24 - 30. Retrieved 2007/10/03.