5-CHLORO-2-FLUORONICOTINALDEHYDE

Base Information

• Chemical Name: 5-CHLORO-2-FLUORONICOTINALDEHYDE
• CAS No.: 882679-90-5
• Molecular Formula: C₆H₃ClFNO
• Molecular Weight: 159.547
• Hs Code.: 2933399090
• Mol file: 882679-90-5.mol

Synonyms:5-Chloro-2-fluoropyridine-3-carboxaldehyde;

Chemical Property of 5-CHLORO-2-FLUORONICOTINALDEHYDE

Chemical Property:

• Vapor Pressure: 0.043mmHg at 25°C
• Refractive Index: 1.565
• Boiling Point: 238.257 °C at 760 mmHg
• Flash Point: 97.894 °C
• PSA: 29.96000
• Density: 1.444 g/cm³
• LogP: 1.68660
• Storage Temp.: Room temperature.

Purity/Quality:

99% ^*data from raw suppliers

5-Chloro-2-fluoronicotinaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Chloro-2-fluoropyridine-3-carboxaldehyde can be used in the preparation of trisubstituted amine compounds as CETP inhibitors useful in the treatment of arteriosclerotic diseases, hyperlipemia, dyslipidemia and related diseases.

Technology Process of 5-CHLORO-2-FLUORONICOTINALDEHYDE

There total 1 articles about 5-CHLORO-2-FLUORONICOTINALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-morpholinecarboxaldehyde (4394-85-8) + 2-fluoro-5-chloropyridine (1480-65-5) → 5-chloro-2-fluoropyridine-3-carbaldehyde (882679-90-5)

Guidance literature:

2-fluoro-5-chloropyridine; With n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -78 ℃; for 1.5h;

4-morpholinecarboxaldehyde; In tetrahydrofuran; for 0.0333333h;

Reference yield:

5-chloro-2-fluoropyridine-3-carbaldehyde (882679-90-5) → 5-chloro-3-(difluoromethyl)-2-fluoropyridine (1119718-20-5)

Guidance literature:

With ethanol; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; dichloromethane; at 20 ℃;

Reference yield:

5-chloro-2-fluoropyridine-3-carbaldehyde (882679-90-5) → (+/-)-1-(5-chloro-2-fluoropyridin-3-yl)ethan-1-one

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 1.25 h / 0 - 20 °C / Inert atmosphere

2: Dess-Martin periodane / dichloromethane / 1.08 h / 0 - 20 °C

With Dess-Martin periodane; In diethyl ether; dichloromethane;

DOI:10.1021/acs.jmedchem.6b01356

upstream raw materials:

4-morpholinecarboxaldehyde

2-fluoro-5-chloropyridine

Downstream raw materials:

5-chloro-3-(difluoromethyl)-2-fluoropyridine

Refernces

• 1、 -. "PYRIMIDINE AND PYRIDINE DERIVATIVES AND USE IN TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA THEREOF". Page/Page column 108; 109. . Retrieved 2017/12/28.