2-[(2-Aminophenyl)-sulfonyl]-ethanol

Base Information

• Chemical Name: 2-[(2-Aminophenyl)-sulfonyl]-ethanol
• CAS No.: 88571-24-8
• Molecular Formula: C8H11 N O3 S
• Molecular Weight: 201.246
• Hs Code.: 2922199090
• Mol file: 88571-24-8.mol

Synonyms:2-Aminophenyl2-hydroxyethyl sulfone; 2-[(2-Aminophenyl)sulfonyl]ethanol

Chemical Property of 2-[(2-Aminophenyl)-sulfonyl]-ethanol

Chemical Property:

• Boiling Point: 462.0±45.0 °C(Predicted)
• PKA: 13.53±0.10(Predicted)
• PSA: 88.77000
• Density: 1.364±0.06 g/cm3(Predicted)
• LogP: 1.69680

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[(2-Aminophenyl)-sulfonyl]-ethanol

There total 3 articles about 2-[(2-Aminophenyl)-sulfonyl]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

→ 2-((2-nitrophenyl)thio)ethan-1-ol (13287-78-0) + 2-<(2-Hydroxyethyl)sulfonyl>aniline (88571-24-8)

Guidance literature:

Reference yield: 27.0%

2-<(2-Hydroxyethyl)thio>aniline (77474-06-7) → 2-<(2-Hydroxyethyl)sulfinyl>aniline (98897-97-3) + 2-<(2-Hydroxyethyl)sulfonyl>aniline (88571-24-8)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1021/ja00183a039

Reference yield:

2-amino-benzenethiol (137-07-5) → 2-<(2-Hydroxyethyl)sulfonyl>aniline (88571-24-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / sodium bicarbonate / H₂O; dioxane / 48 h

2: 27 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 2 h / 0 °C

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; dichloromethane; water;

DOI:10.1021/ja00183a039

upstream raw materials:

2-<(2-Hydroxyethyl)thio>aniline

2-amino-benzenethiol

Downstream raw materials:

2-<(2-Bromoethyl)sulfonyl>aniline hydrobromide

Refernces

• 1、 -. "Process for producing aminophenyl-β-hydroxyethylsulfone". . . Retrieved 2008/06/13.