H-Val-allyl ester p-tosylate

Base Information

• Chemical Name: H-Val-allyl ester p-tosylate
• CAS No.: 88224-02-6
• Molecular Formula: C15H23NO5S
• Molecular Weight: 329.417
• Hs Code.: 2923900090
• Mol file: 88224-02-6.mol

Synonyms:L-Valine allyl ester p-toluenesulfonate;L-Valine allyl ester p-toluenesulfonate salt;prop-2-enyl (2S)-2-amino-3-methylbutanoate, 4-methylbenzenesulfonic acid;

Chemical Property of H-Val-allyl ester p-tosylate

Chemical Property:

• Vapor Pressure: 0.329mmHg at 25°C
• Melting Point: 117-120 °C
• Boiling Point: 200.1 °C at 760 mmHg
• Flash Point: 70.7 °C
• PSA: 115.07000
• LogP: 3.72170
• Storage Temp.: 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

L-Valine allyl ester 4-toluenesulfonate salt ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-Val-allyl ester p-tosylate

There total 1 articles about H-Val-allyl ester p-tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.5%

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) + toluene-4-sulfonic acid (104-15-4) + allyl alcohol (107-18-6) → (S)-1-(allyloxy)-3-methyl-1-oxobutan-2-aminium 4-methylbenzenesulfonate (88224-02-6)

Guidance literature:

In benzene; Heating;

DOI:10.1021/ol051287d

Reference yield: 82.0%

(S)-1-(allyloxy)-3-methyl-1-oxobutan-2-aminium 4-methylbenzenesulfonate (88224-02-6) + cyclohexyl(isopropyl)ammonium (SS)-N-(N-tert-butyloxycarbonyl-L-valinyl)-S-methyl S-phenyl sulfonimidoyl acetate → (SS)-N-(N-tert-butyloxycarbonyl-L-valinyl S-phenyl sulfonimidoyl methyl)-N-(O-allyl-L-valinyl)carboxyamide (188633-84-3)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 13h;

DOI:10.1002/1521-3765(20010302)7:5<1118::AID-CHEM1118>3.0.CO;2-3

Reference yield: 73.0%

(S)-1-(allyloxy)-3-methyl-1-oxobutan-2-aminium 4-methylbenzenesulfonate (88224-02-6) + Cyclohexyl(isopropyl)ammonium (SS)-N-(N-tert-butyloxycarbonyl)-S-methyl S-phenyl sulfonimidoyl acetate → (SS)-N-(N-tert-Butyloxycarbonyl S-phenyl sulfonimidoyl)-N-(O-allyl-L-valinyl)carboxyamide

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 13h;

DOI:10.1002/1521-3765(20010302)7:5<1118::AID-CHEM1118>3.0.CO;2-3

upstream raw materials:

L-valine

toluene-4-sulfonic acid

allyl alcohol

Downstream raw materials:

(S_S)-N-(N-tert-butyloxycarbonyl-L-valinyl S-phenyl sulfonimidoyl methyl)-N-(O-allyl-L-valinyl)carboxyamide

L-valyl-L-phenylalanine methyl ester

Ts-Ala(2'-quinolyl)-Val-Oallyl

Fmoc-Phg-Val-Oallyl

Refernces

• 1、 Goode, David R.,Sharma, Anil K.,Hergenrother, Paul J.. "Using peptidic inhibitors to systematically probe the S1′ site of caspase-3 and caspase-7". . p. 3529 - 3532. Retrieved 2007/10/03.