Technology Process of N-[4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-5-(1-hydroxy-1-methyl-ethyl)-biphenyl-2-yl]-acetamide trifluoroacetic acid
There total 7 articles about N-[4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-5-(1-hydroxy-1-methyl-ethyl)-biphenyl-2-yl]-acetamide trifluoroacetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
methylmagnesium bromide; water;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine / 4 h / 150 °C / Microwave irradiaton
1.2: 0.25 h
2.1: tin(II) chloride dihdyrate / ethanol / 2.83 h / 70 °C
3.1: water; acetonitrile / 18 h / 20 °C
4.1: potassium iodide / acetonitrile / 0.17 h / 110 °C / Microwave irradiation
5.1: potassium acetate; bis(pinacol)diborane / [1,4-bis(diphenylphosphino)butane] palladium(ll) dichloride / 1,4-dioxane / 2.5 h / 80 °C / Argon atmosphere
5.2: 0.28 h / 150 °C / Microwave irradiation
6.1: methylmagnesium bromide; water / tetrahydrofuran / 1 h / 20 °C
With
tin(II) chloride dihdyrate; methylmagnesium bromide; water; potassium acetate; triethylamine; bis(pinacol)diborane; potassium iodide;
[1,4-bis(diphenylphosphino)butane] palladium(ll) dichloride;
In
tetrahydrofuran; 1,4-dioxane; ethanol; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine / 4 h / 150 °C / Microwave irradiaton
1.2: 0.25 h
2.1: tin(II) chloride dihdyrate / ethanol / 2.83 h / 70 °C
3.1: water; acetonitrile / 18 h / 20 °C
4.1: potassium iodide / acetonitrile / 0.17 h / 110 °C / Microwave irradiation
5.1: potassium acetate; bis(pinacol)diborane / [1,4-bis(diphenylphosphino)butane] palladium(ll) dichloride / 1,4-dioxane / 2.5 h / 80 °C / Argon atmosphere
5.2: 0.28 h / 150 °C / Microwave irradiation
6.1: methylmagnesium bromide; water / tetrahydrofuran / 1 h / 20 °C
With
tin(II) chloride dihdyrate; methylmagnesium bromide; water; potassium acetate; triethylamine; bis(pinacol)diborane; potassium iodide;
[1,4-bis(diphenylphosphino)butane] palladium(ll) dichloride;
In
tetrahydrofuran; 1,4-dioxane; ethanol; water; acetonitrile;