DL-3-PYRROLIDINOL

Base Information

• Chemical Name: DL-3-PYRROLIDINOL
• CAS No.: 83220-72-8
• Molecular Formula: C₄H₉NO
• Molecular Weight: 87.1216
• Mol file: 83220-72-8.mol

Synonyms:3-Pyrrolidinol;

Chemical Property of DL-3-PYRROLIDINOL

Chemical Property:

• Refractive Index: n20/D 1.49(lit.)
• Boiling Point: 224.7 °C at 760 mmHg
• Flash Point: 105.8 °C
• PSA: 32.26000
• Density: 1.065 g/cm³
• LogP: -0.33060

Purity/Quality:

99%+, ^*data from raw suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DL-3-PYRROLIDINOL

There total 13 articles about DL-3-PYRROLIDINOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(R)-N-benzyl-3-hydroxypyrrolidine (101385-90-4,101930-07-8,101979-03-7,775-15-5) → (3R)-pyrrolidinol (40499-83-0,83220-72-8,100243-39-8,2799-21-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 2h;

DOI:10.1271/bbb.59.1287

Reference yield: 93.0%

4R-4-hydroxyproline (51-35-4,30724-02-8) → (3R)-pyrrolidinol (40499-83-0,83220-72-8,100243-39-8,2799-21-5)

Guidance literature:

cyclohexenone; In various solvent(s); at 154 ℃; for 2h;

DOI:10.1246/cl.1986.893

Reference yield: 90.0%

(3R)-N(H)-3-(benzyloxy)pyrrolidine (177948-70-8) → (3R)-pyrrolidinol (40499-83-0,83220-72-8,100243-39-8,2799-21-5)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; for 15h; Product distribution / selectivity;

upstream raw materials:

(3S)-1-benzyl-3-hydroxypyrrolidine-2,5-dione

4R-4-hydroxyproline

(R)-N-benzyl-3-hydroxypyrrolidine

(4R)-4-hydroxyproline

Downstream raw materials:

(3R)-1-methoxycarbonylpyrrolidin-2-ol

(R)-1-(3-hydroxypyrrolidin-1-yl)ethan-1-one

(R)-N-(p-nitrophenyl)-3-hydroxypyrrolidine

C₂₄H₃₀F₃N₅O₃

Refernces

• 1、 Afanasyev, Oleg I.,Podyacheva, Evgeniya,Rudenko, Alexander,Tsygankov, Alexey A.,Makarova, Maria,Chusov, Denis. "Redox Condensations of o-Nitrobenzaldehydes with Amines under Mild Conditions: Total Synthesis of the Vasicinone Family". . p. 9347 - 9360. Retrieved 2020/08/14.
• 2、 -. "NOVEL PROCESS FOR THE PREPARATION OF (3SM-[2-(2 J-DIHYDRO-5- BENZOFURANYL?ETHYL]-α.α -DIPHENYL-3-PYRROLIDINEACETAMIDE HYDROBROMIDE". Page/Page column 11; 15-16. . Retrieved 2009/11/29.