2-(2-oxoimidazolidin-1-yl)acetic Acid

Base Information

• Chemical Name: 2-(2-oxoimidazolidin-1-yl)acetic Acid
• CAS No.: 87219-22-5
• Molecular Formula: C5H8N2O3
• Molecular Weight: 144.13
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID10360682
• Wikidata: Q72498764
• Mol file: 87219-22-5.mol

Synonyms:87219-22-5;2-(2-oxoimidazolidin-1-yl)acetic Acid;(2-Oxo-imidazolidin-1-yl)-acetic acid;MFCD04359282;(2-Oxo-Imidazolidin-1-Yl)-AceticAcid;SCHEMBL176995;DTXSID10360682;2-Oxoimidazolidine-1-acetic Acid;SIAWJUIPAYPCEJ-UHFFFAOYSA-N;4-FLUOROMETHYLPHENOXYACETATE;2-(2-oxoimidazolidin-1-yl)aceticAcid;AKOS009150244;AB86698;CS-W006644;DS-16567;SY113023;(2-OXOIMIDAZOLIDIN-1-YL)ACETIC ACID;FT-0699469;EN300-863913;F19879

Chemical Property of 2-(2-oxoimidazolidin-1-yl)acetic Acid

Chemical Property:

• Boiling Point: 487.1 °C at 760 mmHg
• PKA: 4.41±0.10(Predicted)
• Flash Point: 248.4 °C
• PSA: 69.64000
• Density: 1.379 g/cm³
• LogP: -0.63710
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: -1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 144.05349212
• Heavy Atom Count: 10
• Complexity: 168

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Oxoimidazolidin-1-yl)aceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(C(=O)N1)CC(=O)O

Technology Process of 2-(2-oxoimidazolidin-1-yl)acetic Acid

There total 6 articles about 2-(2-oxoimidazolidin-1-yl)acetic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

N-(2-chloroethylcarbamoyl)glycine (87219-18-9) → 2-(2-oxoimidazolidin-1-yl)acetic acid (87219-22-5)

Guidance literature:

With Agepon; In water; for 2h; Heating;

DOI:10.1016/S0040-4020(01)91949-0

Reference yield: 48.0%

2-oxo-imidazolidine-1-ethanol (3699-54-5) → 2-(2-oxoimidazolidin-1-yl)acetic acid (87219-22-5)

Guidance literature:

2-oxo-imidazolidine-1-ethanol; With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hydrogencarbonate; sodium bromide; In water; acetone; at 0 ℃; for 0.166667h;

With trichloroisocyanuric acid; In water; acetone; at 0 - 25 ℃; for 12h;

With hydrogenchloride; In water; pH=~ 2;

Reference yield:

N-(2-chloroethylcarbamoyl)glycine amide (87219-19-0) → 2-(2-oxoimidazolidin-1-yl)acetic acid (87219-22-5)

Guidance literature:

With Agepon; In water; for 2h; Heating;

DOI:10.1016/S0040-4020(01)91949-0

upstream raw materials:

N-(2-chloroethylcarbamoyl)glycine

N-(2-chloroethylcarbamoyl)glycine amide

N-(2-chloroethylcarbamoyl)-glycine methyl ester

N-(2-chloroethylcarbamoyl)glycine t-butyl ester

Refernces

• 1、 -. "2-ARYLTHIAZOLE DERIVATIVES AS CXCR3 RECEPTOR MODULATORS". Page/Page column 96. . Retrieved 2010/11/28.
• 2、 Vargha, H. S.,Medzihradszky-Schweiger, H.,Ruff, F.,Medzihradszky, K.. "CYCLIZATION REACTIONS OF N-(2-CHLOROETHYLCARBAMOYL) AMINO ACIDS". . p. 2255 - 2258. Retrieved 2007/10/02.