tert-butyl benzyl(2-(8-(cyclopentyloxy)-7-methyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)ethyl)carbamate

Base Information

• Chemical Name: tert-butyl benzyl(2-(8-(cyclopentyloxy)-7-methyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)ethyl)carbamate
• CAS No.: 1207984-88-0
• Molecular Formula: C₃₀H₃₅N₅O₅
• Molecular Weight: 545.638
• Mol file: 1207984-88-0.mol

Synonyms:tert-butyl benzyl(2-(8-(cyclopentyloxy)-7-methyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)ethyl)carbamate

Chemical Property of tert-butyl benzyl(2-(8-(cyclopentyloxy)-7-methyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)ethyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl benzyl(2-(8-(cyclopentyloxy)-7-methyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)ethyl)carbamate

There total 9 articles about tert-butyl benzyl(2-(8-(cyclopentyloxy)-7-methyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

Cyclopentanol (96-41-3) + tert-butyl benzyl(2-(8-chloro-7-methyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)ethyl)carbamate (1207984-86-8) → tert-butyl benzyl(2-(8-(cyclopentyloxy)-7-methyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)ethyl)carbamate (1207984-88-0)

Guidance literature:

With sodium hydride; at 70 ℃; for 2h;

Reference yield:

3-chloro-p-toluidine (95-74-9,827571-80-2) → tert-butyl benzyl(2-(8-(cyclopentyloxy)-7-methyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)ethyl)carbamate (1207984-88-0)

Guidance literature:

Multi-step reaction with 10 steps

1.1: dmap; triethylamine / ethyl acetate / 6 h / 0 - 20 °C

2.1: nitric acid; acetic anhydride / acetic acid / 5 h / -10 - 20 °C

3.1: methanol; sodium methylate / 5 h / 20 °C

4.1: ammonium chloride / ethanol / Reflux; Inert atmosphere

5.1: sodium tetrahydroborate / ethanol / 12 h / Reflux

5.2: 0 - 20 °C

6.1: boron trioxide; acetic acid / 14 h / 20 - 70 °C / Inert atmosphere

7.1: sulfuric acid; periodic acid / water / 0 - 20 °C

7.2: pH 3.8 - 3.9

8.1: acetic acid / ethanol / 20 - 40 °C

8.2: 2 h / 20 °C

9.1: triethylamine / methanol / 2 h / 20 °C

10.1: sodium hydride / 2 h / 70 °C

With methanol; dmap; boron trioxide; sodium tetrahydroborate; sulfuric acid; nitric acid; sodium methylate; acetic anhydride; sodium hydride; ammonium chloride; acetic acid; periodic acid; triethylamine; In methanol; ethanol; water; acetic acid; ethyl acetate;

Reference yield:

5-chloro-4-methyl-2-nitroacetanilide (7149-78-2) → tert-butyl benzyl(2-(8-(cyclopentyloxy)-7-methyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)ethyl)carbamate (1207984-88-0)

Guidance literature:

Multi-step reaction with 8 steps

1.1: methanol; sodium methylate / 5 h / 20 °C

2.1: ammonium chloride / ethanol / Reflux; Inert atmosphere

3.1: sodium tetrahydroborate / ethanol / 12 h / Reflux

3.2: 0 - 20 °C

4.1: boron trioxide; acetic acid / 14 h / 20 - 70 °C / Inert atmosphere

5.1: sulfuric acid; periodic acid / water / 0 - 20 °C

5.2: pH 3.8 - 3.9

6.1: acetic acid / ethanol / 20 - 40 °C

6.2: 2 h / 20 °C

7.1: triethylamine / methanol / 2 h / 20 °C

8.1: sodium hydride / 2 h / 70 °C

With methanol; boron trioxide; sodium tetrahydroborate; sulfuric acid; sodium methylate; sodium hydride; ammonium chloride; acetic acid; periodic acid; triethylamine; In methanol; ethanol; water;

upstream raw materials:

Cyclopentanol

tert-butyl benzyl(2-(8-chloro-7-methyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)ethyl)carbamate

(8-chloro-7-methyl-2,4-dioxo-3,4-dihydro-2H-benzo[g]pteridin-10-yl)-acetaldehyde

2-(5-chloro-4-methyl-2-nitrophenylamino)tetrahydropyran-3,4,5-triol

Downstream raw materials:

10-(2-(benzylamino)ethyl)-8-(cyclopentyloxy)-7-methylbenzo[g]pteridine-2,4(3H,10H)-dione trifluoroacetate

Refernces