1-Trifluoromethyl-1-cyclohexanol

Base Information

• Chemical Name: 1-Trifluoromethyl-1-cyclohexanol
• CAS No.: 80768-55-4
• Molecular Formula: C7H11 F3 O
• Molecular Weight: 168.159
• Mol file: 80768-55-4.mol

Synonyms:1-(Trifluoromethyl)cyclohexanol

Chemical Property of 1-Trifluoromethyl-1-cyclohexanol

Chemical Property:

• PSA: 20.23000
• LogP: 2.24390

Purity/Quality:

98% ^*data from raw suppliers

1-(Trifluoromethyl)cyclohexanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Trifluoromethyl-1-cyclohexanol

There total 10 articles about 1-Trifluoromethyl-1-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

trifluoromethan (75-46-7) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1-(trifluoromethyl)-1-cyclohexanol (80768-55-4)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 6h; Time; Inert atmosphere;

Reference yield: 76.0%

iodotrifluoromethane (2314-97-8,263005-66-9) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1-(trifluoromethyl)-1-cyclohexanol (80768-55-4)

Guidance literature:

With Tetrakis(dimethylamino)ethylen; In N,N-dimethyl-formamide; at -20 - 20 ℃; for 8.16667h; Irradiation;

DOI:10.1021/ol016933x

Reference yield: 69.0%

→ 1-(trifluoromethyl)-1-cyclohexanol (80768-55-4)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 6h; Inert atmosphere;

upstream raw materials:

Bromotrifluoromethane

cyclohexanone

iodotrifluoromethane

trifluoronitrosomethane

Downstream raw materials:

1-(trifluoromethyl)-1-cyclohexene

trifluoromethylcyclohexane

Refernces

• 1、 -. "PREPARATION PROCESS OF PERFLUOROALKYL COMPOUND WITH MONOHYDROPERFLUOROALKANE AS STARTING MATERIAL". Paragraph 0072-0076; 0087-0091. . Retrieved 2019/06/17.
• 2、 Chang, Ying,Cai, Chun. "Sodium trifluoroacetate: An efficient precursor for the trifluoromethylation of aldehydes". . p. 3161 - 3164. Retrieved 2007/10/03.