DESTHIOBIOTIN N-HYDROXYSUCCINIMIDYL ESTER

Base Information

• Chemical Name: DESTHIOBIOTIN N-HYDROXYSUCCINIMIDYL ESTER
• CAS No.: 80750-24-9
• Molecular Formula: C₁₄H₂₁N₃O₅
• Molecular Weight: 311.338
• Mol file: 80750-24-9.mol

Synonyms:2,5-Pyrrolidinedione,1-[[6-(5-methyl-2-oxo-4-imidazolidinyl)-1-oxohexyl]oxy]-, (4R-cis)- (9CI);N-Hydroxysuccinimido dethiobiotinate

Chemical Property of DESTHIOBIOTIN N-HYDROXYSUCCINIMIDYL ESTER

Chemical Property:

• PSA: 104.81000
• LogP: 1.20950

Purity/Quality:

99% ^*data from raw suppliers

DesthiobiotinN-HydroxysuccinimideEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Desthiobiotin N-Hydroxysuccinimide Ester is used as a reactant in the preparation of fluorescein-labeled Dethiobiotin (D297663) probe for continuous fluorescence displacement assay of BioA enzyme activity. BioA is an enzyme involved in the Biotin (B389040) biosynthesis

Technology Process of DESTHIOBIOTIN N-HYDROXYSUCCINIMIDYL ESTER

There total 2 articles about DESTHIOBIOTIN N-HYDROXYSUCCINIMIDYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + desthiobiotin (533-48-2) → NHS-desthiobiotin (80750-24-9)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1021/jacs.9b13621

Reference yield: 60.0%

Desthiobiotin (15720-25-9) + sodium citrate (68-04-2) → NHS-desthiobiotin (80750-24-9)

Guidance literature:

Reference yield: 100.0%

NHS-desthiobiotin (80750-24-9) + 2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethylamine (134179-38-7) → C18H34N6O5 (1306615-47-3,1426828-06-9)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; pH=9;

DOI:10.1021/jacs.9b03597

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

desthiobiotin

Desthiobiotin

sodium citrate

Downstream raw materials:

C₁₈H₃₄N₆O₅

Refernces

• 1、 Cheng, Yangyang,Derivery, Emmanuel,González-Gaitán, Marcos,López-Andarias, Javier,Laurent, Quentin,Matile, Stefan,Moreau, Dimitri,Saarbach, Jacques,Sakai, Naomi,Winssinger, Nicolas. "Cell-Penetrating Streptavidin: A General Tool for Bifunctional Delivery with Spatiotemporal Control, Mediated by Transport Systems Such as Adaptive Benzopolysulfane Networks". . p. 4784 - 4792. Retrieved 2020.
• 2、 -. "POLYCYCLIC EPOXIDES AND COMPOSITIONS THEREOF WITH ANTI-CANCER ACTIVITIES". Paragraph 0328-0331. . Retrieved 2016/12/01.