Technology Process of Ac-Asn-dmP-Tyr
There total 6 articles about Ac-Asn-dmP-Tyr which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Ac-N(Trt)-dmP-OH; NH2-Y(Ot-Bu)-Novasyn resin;
With
benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate;
With
trifluoroacetic acid;
In
various solvent(s);
DOI:10.1021/ja9930317
- Guidance literature:
-
Multi-step reaction with 6 steps
2.1: SOCl2
3.1: DCC / dimethylformamide
4.1: aq. NaOH / methanol
6.1: TBTU; HOBt
6.2: 58 percent / TFA / various solvent(s)
With
sodium hydroxide; thionyl chloride; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; dicyclohexyl-carbodiimide;
In
methanol; N,N-dimethyl-formamide;
1.1: PUR via salt with D-tartaric acid / 2.1: Esterification / 3.1: Condensation / 4.1: Hydrolysis / 5.1: Acetylation / 6.1: Condensation / 6.2: deprotection;
DOI:10.1021/ja9930317
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: DCC / dimethylformamide
2.1: aq. NaOH / methanol
4.1: TBTU; HOBt
4.2: 58 percent / TFA / various solvent(s)
With
sodium hydroxide; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; dicyclohexyl-carbodiimide;
In
methanol; N,N-dimethyl-formamide;
1.1: Condensation / 2.1: Hydrolysis / 3.1: Acetylation / 4.1: Condensation / 4.2: deprotection;
DOI:10.1021/ja9930317
