4-amino-3,5,6-trifluorophthalic acid

Base Information

• Chemical Name: 4-amino-3,5,6-trifluorophthalic acid
• CAS No.: 169542-84-1
• Molecular Formula: C₈H₄F₃NO₄
• Molecular Weight: 235.119
• Mol file: 169542-84-1.mol

Synonyms:4-amino-3,5,6-trifluorophthalic acid

Chemical Property of 4-amino-3,5,6-trifluorophthalic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-amino-3,5,6-trifluorophthalic acid

There total 1 articles about 4-amino-3,5,6-trifluorophthalic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3,4,5,6-tetrafluorophthalic acid (652-03-9) → 4-amino-3,5,6-trifluorophthalic acid (169542-84-1)

Guidance literature:

With ammonia; at 110 ℃; for 100h; Autoclave;

DOI:10.1016/j.jfluchem.2011.09.010

Reference yield: 80.0%

4-amino-3,5,6-trifluorophthalic acid (169542-84-1) → 3-amino-2,4,5-trifluorobenzoic acid (119385-80-7)

Guidance literature:

With sulfuric acid; ammonium chloride; triethylamine; In water; at 130 ℃; for 170h; Sealed tube;

DOI:10.1016/j.jfluchem.2011.09.010

Reference yield:

4-amino-3,5,6-trifluorophthalic acid (169542-84-1) → 3-acetamido-2,4,5-trifluorobenzoic acid (1359986-43-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; ammonium chloride; triethylamine / water / 170 h / 130 °C / Sealed tube

2: benzene

With sulfuric acid; ammonium chloride; triethylamine; In water; benzene;

DOI:10.1016/j.jfluchem.2011.09.010

upstream raw materials:

3,4,5,6-tetrafluorophthalic acid

Downstream raw materials:

3-amino-2,4,5-trifluorobenzoic acid

3-acetamido-2,4,5-trifluorobenzoic acid

N-pentafluorophenyl-4-amino-3,5,6-trifluorophthalimide

Refernces