2-(2,4'-difluorobiphenyl-4-yl)-2,2-difluoroacetamide

Base Information

• Chemical Name: 2-(2,4'-difluorobiphenyl-4-yl)-2,2-difluoroacetamide
• CAS No.: 1279100-87-6
• Molecular Formula: C₁₄H₉F₄NO
• Molecular Weight: 283.225
• Mol file: 1279100-87-6.mol

Synonyms:2-(2,4'-difluorobiphenyl-4-yl)-2,2-difluoroacetamide

Chemical Property of 2-(2,4'-difluorobiphenyl-4-yl)-2,2-difluoroacetamide

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of 2-(2,4'-difluorobiphenyl-4-yl)-2,2-difluoroacetamide

There total 1 articles about 2-(2,4'-difluorobiphenyl-4-yl)-2,2-difluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-( 4-bromo-3-fluorophenyl)acetonitrile (499983-13-0) → 2-(2,4'-difluorobiphenyl-4-yl)-2,2-difluoroacetamide (1279100-87-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrabutylammomium bromide; palladium diacetate; sodium carbonate / water / 120 °C / Inert atmosphere

2.1: tert.-butyl lithium / tetrahydrofuran / 1.03 h / -78 °C / Inert atmosphere

2.2: 3.03 h / -78 °C / Inert atmosphere

3.1: dihydrogen peroxide; potassium carbonate / dimethyl sulfoxide / 0 - 25 °C / Inert atmosphere

With tetrabutylammomium bromide; dihydrogen peroxide; tert.-butyl lithium; palladium diacetate; sodium carbonate; potassium carbonate; In tetrahydrofuran; water; dimethyl sulfoxide; 1.1: Suzuki coupling;

DOI:10.1021/jm101450p

upstream raw materials:

2-( 4-bromo-3-fluorophenyl)acetonitrile

Refernces