4-(2-methoxy-4-(trifluoromethyl)phenyl)-3-methylpyridine hydrochloride

Base Information

• Chemical Name: 4-(2-methoxy-4-(trifluoromethyl)phenyl)-3-methylpyridine hydrochloride
• CAS No.: 1004619-04-8
• Molecular Formula: C₁₄H₁₂F₃NO*ClH
• Molecular Weight: 303.712
• Mol file: 1004619-04-8.mol

Synonyms:4-(2-methoxy-4-(trifluoromethyl)phenyl)-3-methylpyridine hydrochloride

Chemical Property of 4-(2-methoxy-4-(trifluoromethyl)phenyl)-3-methylpyridine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-methoxy-4-(trifluoromethyl)phenyl)-3-methylpyridine hydrochloride

There total 3 articles about 4-(2-methoxy-4-(trifluoromethyl)phenyl)-3-methylpyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-methoxy-4-(trifluoromethyl)phenyl)-3-methylpyridine (1004619-03-7) → 4-(2-methoxy-4-(trifluoromethyl)phenyl)-3-methylpyridine hydrochloride (1004619-04-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

Reference yield:

4-bromo-3-methylpyridine (10168-00-0) + (2-methoxy-4-(trifluoromethyl)phenyl)boronic acid (312936-89-3) → 4-(2-methoxy-4-(trifluoromethyl)phenyl)-3-methylpyridine hydrochloride (1004619-04-8)

Guidance literature:

4-bromo-3-methylpyridine; (2-methoxy-4-(trifluoromethyl)phenyl)boronic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,2-dimethoxyethane; water; at 85 ℃; Inert atmosphere;

With hydrogenchloride; In 1,4-dioxane; dichloromethane; water;

DOI:10.1021/jm101414h

Reference yield:

3-(trifluoromethyl)anisole (454-90-0) → 4-(2-methoxy-4-(trifluoromethyl)phenyl)-3-methylpyridine hydrochloride (1004619-04-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

1.3: 1 h

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,2-dimethoxyethane; water / 85 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium hydrogencarbonate; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; water; 2.1: Suzuki coupling;

DOI:10.1021/jm101414h

upstream raw materials:

4-(2-methoxy-4-(trifluoromethyl)phenyl)-3-methylpyridine

3-(trifluoromethyl)anisole

4-bromo-3-methylpyridine

(2-methoxy-4-(trifluoromethyl)phenyl)boronic acid

Refernces

• 1、 -. "AZABENZIMIDAZOLYL COMPOUNDS". Page/Page column 67. . Retrieved 2008/06/13.