5-FLUOROTHIAZOL-2-AMINE HYDROCHLORIDE

Base Information

• Chemical Name: 5-FLUOROTHIAZOL-2-AMINE HYDROCHLORIDE
• CAS No.: 745053-64-9
• Molecular Formula: C3H3 F N2 S . Cl H
• Molecular Weight: 154.596
• Hs Code.: 2934100090
• Mol file: 745053-64-9.mol

Synonyms:2-Thiazolamine,5-fluoro-, monohydrochloride (9CI); (5-Fluorothiazol-2-yl)amine hydrochloride;(5-Fluorothiazol-2-yl)amine monohydrochloride; 5-Fluorothiazol-2-ylaminehydrochloride

Chemical Property of 5-FLUOROTHIAZOL-2-AMINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.105mmHg at 25°C
• Melting Point: 138-143°C
• Boiling Point: 221.8°C at 760 mmHg
• Flash Point: 88°C
• PSA: 67.15000
• LogP: 2.24760
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

5-Fluorothiazol-2-amineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Fluorothiazol-2-amine Hydrochloride can be used as anti-tumor agents.

Technology Process of 5-FLUOROTHIAZOL-2-AMINE HYDROCHLORIDE

There total 4 articles about 5-FLUOROTHIAZOL-2-AMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-acetamido-5-fluorothiazole (876379-99-6) → 5-fluoro-1,3-thiazol-2-amine hydrochloride (745053-64-9)

Guidance literature:

With hydrogenchloride; In water; at 70 - 75 ℃; for 16h;

DOI:10.1021/op0502194

Reference yield: 96.0%

2-(tert-butoxycarbonyl)amino-5-fluorothiazole (731018-54-5) → 5-fluoro-1,3-thiazol-2-amine hydrochloride (745053-64-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 35 ℃; for 5h; Large scale;

DOI:10.1021/op0502194

Reference yield: 96.0%

N-(5-fluorothiazol-2-yl)-2,2,2-trifluoroacetamide (745053-67-2) → 5-fluoro-1,3-thiazol-2-amine hydrochloride (745053-64-9)

Guidance literature:

With acetyl chloride; In methanol; Reflux;

DOI:10.1021/op0502194

upstream raw materials:

N-(5-fluorothiazol-2-yl)-2,2,2-trifluoroacetamide

2-(tert-butoxycarbonyl)amino-5-fluorothiazole

2-acetamido-5-fluorothiazole

2-aminothiazole-5-carboxylic acid

Downstream raw materials:

5-fluoro-1,3-thiazol-2-amine

PSN-GK1

C₁₈H₁₉FN₄O₄S₂

(4-fluorophenyl)(4-(5-fluorothiazol-2-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)methanone

Refernces

• 1、 -. "PROCESS FOR THE PRODUCTION OF 2-AMINO-5-FLUOROTHIAZOLE". Page/Page column 13-14. . Retrieved 2011/10/10.
• 2、 Briner, Paul H.,Fyfe, Matthew C. T.,Martin, Pierre,Murray, P. John,Naud, Frederic,Procter, Martin J.. "Practical synthesis of 2-amino-5-fluorothiazole hydrochloride". . p. 346 - 348. Retrieved 2012/12/22.