trans-octahydroindole-2-carboxylic acid

Base Information

• Chemical Name: trans-octahydroindole-2-carboxylic acid
• CAS No.: 144540-74-9
• Molecular Formula: C₉H₁₅NO₂*ClH
• Molecular Weight: 205.685
• Mol file: 144540-74-9.mol

Synonyms:trans-octahydroindole-2-carboxylic acid

Chemical Property of trans-octahydroindole-2-carboxylic acid

Chemical Property:

Purity/Quality:

>95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-octahydroindole-2-carboxylic acid

There total 1 articles about trans-octahydroindole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3.3a,4,5,6,7-2H-Hexahydroindole-2-carboxylic acid hydrochloride → octahydroindole-2-carboxylic acid hydrochloride (84324-13-0,87679-23-0,88547-78-8,97975-67-2,110623-68-2,116184-24-8,144540-74-9,144540-75-0,1004292-98-1)

Guidance literature:

With hydrogen; acetic acid; platinum on activated charcoal; at 60 - 70 ℃; Industry scale;

Reference yield: 78.0%

trans-octahydroindole-2-carboxylic acid (144540-74-9,1004292-98-1) + benzyl alcohol (100-51-6,185532-71-2) → (2R,3aR,7aS)-Octahydro-indole-2-carboxylic acid benzyl ester; hydrochloride (145682-37-7)

Guidance literature:

With thionyl chloride; In dichloromethane; for 4h; Ambient temperature;

DOI:10.1016/S0040-4039(00)61225-X

Reference yield:

octahydroindole-2-carboxylic acid hydrochloride (84324-13-0,87679-23-0,88547-78-8,97975-67-2,110623-68-2,116184-24-8,144540-74-9,144540-75-0,1004292-98-1) + benzyl alcohol (100-51-6,185532-71-2) → phenylmethyl octahydroindole-2-carboxylate hydrochloride

Guidance literature:

octahydroindole-2-carboxylic acid hydrochloride; benzyl alcohol; toluene-4-sulfonic acid; In toluene; Industry scale; Heating / reflux;

In water; toluene; pH=10.5; Industry scale;

With hydrogenchloride; In methanol; Industry scale;

Downstream raw materials:

(2R,3aR,7aS)-Octahydro-indole-2-carboxylic acid benzyl ester; hydrochloride

Refernces