1H-Indazol-5-amine,6-fluoro-(9CI)

Base Information

• Chemical Name: 1H-Indazol-5-amine,6-fluoro-(9CI)
• CAS No.: 709046-14-0
• Molecular Formula: C7H6FN3
• Molecular Weight: 151.143
• Hs Code.: 2933998090
• Mol file: 709046-14-0.mol

Synonyms:5-Amino-6-fluoroindazole;6-Fluoro-1H-indazol-5-amine;

Chemical Property of 1H-Indazol-5-amine,6-fluoro-(9CI)

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.737
• Boiling Point: 358.374 °C at 760 mmHg
• PKA: 13.73±0.40(Predicted)
• Flash Point: 170.539 °C
• PSA: 54.70000
• Density: 1.488g/cm³
• LogP: 1.86540
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99.5% ^*data from raw suppliers

6-Fluoro-1H-indazol-5-amine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indazol-5-amine,6-fluoro-(9CI)

There total 5 articles about 1H-Indazol-5-amine,6-fluoro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-nitro-6-fluoro-1H-indazole (633327-51-2) → 5-amino-6-fluoro-1H-indazole (709046-14-0)

Guidance literature:

With palladium on activated charcoal; In ethyl acetate; at 20 ℃;

Reference yield: 93.0%

→ 5-amino-6-fluoro-1H-indazole (709046-14-0)

Guidance literature:

Reference yield:

3-fluoro-6-methylaniline (367-29-3) → 5-amino-6-fluoro-1H-indazole (709046-14-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium acetate / CHCl₃ / 20 - 40 °C

1.2: isoamyl nitrite / CHCl₃ / 18 h / 60 °C

2.1: 4.80 g / HCl / methanol / 5 h / 80 °C

3.1: 3.00 g / sodium nitrate; H₂SO₄ / H₂O / 1 h / 20 °C

4.1: 1.67 g / SnCl₂*2H₂O; HCl / H₂O / 5 h / 20 °C

With hydrogenchloride; sodium nitrate; sulfuric acid; potassium acetate; tin(ll) chloride; In methanol; chloroform; water;

DOI:10.1016/j.bmc.2004.02.025

upstream raw materials:

5-nitro-6-fluoro-1H-indazole

3-fluoro-6-methylaniline

6-fluoro-1H-indazole

6-fluoro-1-acetylindazole

Downstream raw materials:

tert-butyl 5-((tert-butoxycarbonyl)(2-(3-(2-(isopropylamino)-2-oxoethoxy)phenyl)pyrimidin-4-yl)amino)-6-fluoro-1H-indazole-1-carboxylate

GSK429286

Refernces

• 1、 -. "a-AMINO ACID DERIVATIVE AND PHARMACEUTICAL COMPRISING THE SAME AS ACTIVE INGREDIENT". Page/Page column 48. . Retrieved 2009/04/23.