2-(2-Chloroethyl)pyridine hydrochloride

Base Information

• Chemical Name: 2-(2-Chloroethyl)pyridine hydrochloride
• CAS No.: 4226-37-3
• Molecular Formula: C7H9Cl2N
• Molecular Weight: 178.0591
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID70195093
• Mol file: 4226-37-3.mol

Synonyms:2-(2-Chloroethyl)pyridine hydrochloride;4226-37-3;2-(2-Chloroethyl)pyridine hcl;2-(2-chloroethyl)pyridine;hydrochloride;Pyridine, 2-(2-chloroethyl)-, hydrochloride;MFCD01691965;2-(2-Chloroethyl)pyridinehydrochloride;2-(2-pyridinyl)ethyl chloride hydrochloride;SCHEMBL178022;DTXSID70195093;2-(chloroethyl)pyridine hydrochloride;AKOS005259724;SB52865;2-(2-chloroethyl) pyridine.hydrochloride;2-(chloroethyl)pyridine hydrogen chloride;LS-131086;CS-0217532;EN300-7646452;A872920

Chemical Property of 2-(2-Chloroethyl)pyridine hydrochloride

Chemical Property:

• Vapor Pressure: 0.294mmHg at 25°C
• Boiling Point: 209.4 °C at 760 mmHg
• Flash Point: 100 °C
• PSA: 12.89000
• LogP: 2.66490
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 177.0112047
• Heavy Atom Count: 10
• Complexity: 75.3

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Chloroethyl)pyridine hydrochloride 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)CCCl.Cl

Technology Process of 2-(2-Chloroethyl)pyridine hydrochloride

There total 1 articles about 2-(2-Chloroethyl)pyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

2-(2-Hydroxyethyl)pyridine (103-74-2) → 2-(2-pyridinyl)ethyl chloride hydrochloride (4226-37-3)

Guidance literature:

With thionyl chloride; In tetrahydrofuran; for 16h; Reflux;

Reference yield: 68.0%

2-(2-pyridinyl)ethyl chloride hydrochloride (4226-37-3) + methyl 4-[N-(1-oxopropyl)-N-phenylamino]-4-piperidinecarboxylate (72996-78-2)

Guidance literature:

With sodium carbonate; sodium iodide; In acetonitrile; Heating;

DOI:10.1021/jm00106a051

Reference yield: 39.0%

2-(2-pyridinyl)ethyl chloride hydrochloride (4226-37-3) + combrestatin A4 (117048-62-1,117048-59-6) → 3'-O-[2''-(2''-pyridyl)ethyl]-combretastatin A-4

Guidance literature:

combrestatin A₄; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

2-(2-pyridinyl)ethyl chloride hydrochloride; In N,N-dimethyl-formamide; at 90 ℃; for 12h;

DOI:10.1021/jm0205797

upstream raw materials:

2-(2-Hydroxyethyl)pyridine

Downstream raw materials:

benzyl-(2-chloro-ethyl)-(2-[2]pyridyl-ethyl)-amine

Refernces

• 1、 -. "AZINONE-SUBSTITUTED AZEPINO[b]INDOLE AND PYRIDO-PYRROLO-AZEPINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF". Page/Page column 82. . Retrieved 2011/01/12.