1-Piperidinecarboxylicacid,2-methyl-4-oxo-,1,1-dimethylethylester,(2S)-(9CI)

Base Information

• Chemical Name: 1-Piperidinecarboxylicacid,2-methyl-4-oxo-,1,1-dimethylethylester,(2S)-(9CI)
• CAS No.: 790667-49-1
• Molecular Formula: C11H19 N O3
• Molecular Weight: 213.277
• Mol file: 790667-49-1.mol

Synonyms:(2S)-2-Methyl-4-oxo-piperidine-1-carboxylicacid tert-butyl ester

Chemical Property of 1-Piperidinecarboxylicacid,2-methyl-4-oxo-,1,1-dimethylethylester,(2S)-(9CI)

Chemical Property:

• Boiling Point: 298.8±33.0 °C(Predicted)
• PKA: -1.52±0.40(Predicted)
• PSA: 46.61000
• Density: 1.060±0.06 g/cm3(Predicted)
• LogP: 1.91280
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

tert-Butyl (2S)-2-methyl-4-oxopiperidine-1-carboxylate 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylicacid,2-methyl-4-oxo-,1,1-dimethylethylester,(2S)-(9CI)

There total 6 articles about 1-Piperidinecarboxylicacid,2-methyl-4-oxo-,1,1-dimethylethylester,(2S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl (2S)-2-methyl-4-oxopiperidine-1-carboxylate (921599-74-8,852051-10-6) + di-tert-butyl dicarbonate (24424-99-5) → (S)-2-methyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester (790667-49-1)

Guidance literature:

With palladium on activated charcoal; hydrogen; In tetrahydrofuran; ethanol; for 18h; under 775.743 Torr;

Reference yield: 95.0%

(S)-2-methylpiperidin-4-one hydrochloride (790667-45-7,13729-77-6,1434126-97-2) + di-tert-butyl dicarbonate (24424-99-5) → (S)-2-methyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester (790667-49-1)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; water; at 20 ℃;

Reference yield: 55.0%

di-tert-butyl dicarbonate (24424-99-5) + (S)-2-methyl-1-((S)-1-phenyl-ethyl)piperidin-4-one (89467-36-7) → (S)-2-methyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester (790667-49-1)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; hydrogen; In tetrahydrofuran; at 20 ℃; for 16h; under 2585.81 Torr;

upstream raw materials:

2-methyl-4-oxopiperidine

di-tert-butyl dicarbonate

(S)-2-methyl-1-((S)-1-phenyl-ethyl)piperidin-4-one

(S)-2-methylpiperidin-4-one hydrochloride

Refernces

• 1、 -. "N-SUBSTITUTED TETRAHYDROTHIENOPYRIDINE DERIVATIVES AND USES THEREOF". Paragraph 00239. . Retrieved 2020/01/11.
• 2、 -. "PYRAZOLO PYRIMIDINE DERIVATIVES". Paragraph 0340-0341. . Retrieved 2013/03/26.