(R)-2-Methylmorpholine

Base Information

• Chemical Name: (R)-2-Methylmorpholine
• CAS No.: 790184-33-7
• Molecular Formula: C5H11NO
• Molecular Weight: 101.148
• Hs Code.: 2934999090
• Mol file: 790184-33-7.mol

Synonyms:Morpholine,2-methyl-, (R)- (9CI);(R)-2-Methylmorpholine;

Chemical Property of (R)-2-Methylmorpholine

Chemical Property:

• Boiling Point: 137.1 °C at 760 mmHg
• PKA: 9.01±0.40(Predicted)
• Flash Point: 41.3 °C
• PSA: 21.26000
• Density: 0.891 g/cm³
• LogP: 0.32350

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-2-Methylmorpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-2-Methylmorpholine

There total 10 articles about (R)-2-Methylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(2R)-2-methyl-4-tosyl-morpholine → (2R)-2-methyl-morpholine (790184-33-7)

Guidance literature:

With hydrogen bromide; phenol; In acetic acid; at 20 ℃; for 16h;

Reference yield: 84.0%

(R)-4-benzyl-2-methylmorpholine (120800-90-0) → (2R)-2-methyl-morpholine (790184-33-7)

Guidance literature:

With 2-Chloroethyl chloroformate; In dichloromethane; for 2.5h; Cooling with ice; Reflux; Green chemistry;

Reference yield: 70.0%

(6R)-6-methylmorpholin-3-one (127958-66-1,127958-63-8) → (2R)-2-methyl-morpholine (790184-33-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

DOI:10.1055/s-0034-1379641

upstream raw materials:

(3R,6aS,9R,10aR,11aS)-3,6,6,9-tetramethyl-decahydro-3H,7H-[1,4]oxazino[3,4-b][1,3]benzoxazine

(2R)-4-(8-mentholyl)-2-methyl-morpholine

(3S,6aS,9R,10aR,11aS)-3-phenylselenenylmethyl-6,6,9-trimethyl-decahydro-3H,7H-[1,4]oxazino[3,4-b][1,3]benzoxazine

(2S,4aS,7R,8aR)-N-allyl-2-hydroxymethyl-4,4,7-trimethyl-octahydro-1,3-benzoxazine

Downstream raw materials:

5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-3-((R)-2-methyl-morpholin-4-yl)-3-oxo-propyl]-amide

2-[(2R)-2-methylmorpholin-4-yl]-N-[6-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-2-yl]acetamide

2-[(2S)-2-methylmorpholin-4-yl]-N-[6-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-2-yl]acetamide

2-[(2R)-2-methylmorpholin-4-yl]-N-[6-(2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidin-9-yl)dibenzothiophen-2-yl]acetamide

Refernces

• 1、 Dugar, Sundeep,Sharma, Amit,Kuila, Bilash,Mahajan, Dinesh,Dwivedi, Sandeep,Tripathi, Vinayak. "A concise and efficient synthesis of substituted morpholines". supporting information. . Retrieved 2015/02/19.
• 2、 Pedrosa, Rafael,Andres, Celia,Mendiguchia, Pilar,Nieto, Javier. "Diastereoselective synthesis of enantiopure morphelines by electrophilic selenium-induced 6-exo cyclizations on chiral 3-allyl-2-hydroxymethylperhydro-1, 3-benzoxazine derivatives". . p. 8854 - 8863. Retrieved 2007/10/03.