4-ACETAMIDO-3-NITROPYRIDINE

Base Information

• Chemical Name: 4-ACETAMIDO-3-NITROPYRIDINE
• CAS No.: 79371-42-9
• Molecular Formula: C7H7N3O3
• Molecular Weight: 181.151
• Hs Code.: 29333990
• Mol file: 79371-42-9.mol

Synonyms:N-(3-Nitro-4-pyridyl)acetamide;4-(Acetylamino)-3-nitropyridine;3-Nitro-4-(acetylamino)pyridine;N-(3-nitropyridin-4-yl)acetamide;N-(3-Nitropyridin-4-yl)acetamide;

Chemical Property of 4-ACETAMIDO-3-NITROPYRIDINE

Chemical Property:

• Boiling Point: 414.4 °C at 760 mmHg
• Flash Point: 204.4 °C
• PSA: 87.81000
• Density: 1.419 g/cm³
• LogP: 1.54440

Purity/Quality:

99% ^*data from raw suppliers

4-Acetamido-3-nitropyridine 98% ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22
• Safety Statements: 24/25-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-ACETAMIDO-3-NITROPYRIDINE

There total 4 articles about 4-ACETAMIDO-3-NITROPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-acetylaminopyridine (5221-42-1) → N-(3-nitropyridin-4-yl)acetamide (79371-42-9)

Guidance literature:

With dinitrogen pentoxide; In nitromethane; at 0 ℃; for 0.166667h;

DOI:10.1002/jhet.5570360505

Reference yield: 72.0%

→ N-(3-nitropyridin-4-yl)acetamide (79371-42-9)

Guidance literature:

Reference yield:

4-aminopyridine (504-24-5) → N-(3-nitropyridin-4-yl)acetamide (79371-42-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / Et₃N / acetonitrile / 1 h / 20 °C

2: 72 percent / N₂O₅ / nitromethane / 0.17 h / 0 °C

With dinitrogen pentoxide; triethylamine; In nitromethane; acetonitrile; 1: Acetylation / 2: Nitration;

DOI:10.1002/jhet.5570360505

upstream raw materials:

4-amino-3-nitropyridine

acetic anhydride

4-acetylaminopyridine

4-aminopyridine

Downstream raw materials:

N-(3-aminopyridin-4-yl)acetamide

2-methyl-1H-imidazo[4,5-c]pyridine

3,4-diaminopyridine

4-amino-3-nitropyridine

Refernces

• 1、 -. "Aminopyridine compounds". . . Retrieved 2008/06/13.