2-Benzothiazolamine,4,5-dimethyl-(9CI)

Base Information

• Chemical Name: 2-Benzothiazolamine,4,5-dimethyl-(9CI)
• CAS No.: 79050-49-0
• Molecular Formula: C9H10N2S
• Molecular Weight: 178.258
• Hs Code.: 29342000
• Mol file: 79050-49-0.mol

Synonyms:2-Amino-4,5-dimethylbenzothiazole;

Chemical Property of 2-Benzothiazolamine,4,5-dimethyl-(9CI)

Chemical Property:

• Boiling Point: 342.1 °C at 760 mmHg
• Flash Point: 160.7 °C
• PSA: 67.15000
• Density: 1.263 g/cm³
• LogP: 3.07650

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-4,5-dimethylbenzothiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Amino-4,5-dimethylbenzothiazole is a reagent used in the synthesis of a series of substituted pyrimido[2,1-b]benzothiazoles which exhibit antimicrobial activity. 2-Amino-4,5-dimethylbenzothiazole can also be used as a potential modulator of SKCa, IKCa, and BKCa channels.

Technology Process of 2-Benzothiazolamine,4,5-dimethyl-(9CI)

There total 6 articles about 2-Benzothiazolamine,4,5-dimethyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-Dimethylaniline (87-59-2) → 2-amino-4,5-dimethylbenzothiazole (79050-49-0)

Guidance literature:

Reference yield:

1-(2,3-dimethylphenyl)thiourea (55752-58-4) → 2-amino-4,5-dimethylbenzothiazole (79050-49-0)

Guidance literature:

With ammonium hydroxide; bromine; acetic acid; Yield given. Multistep reaction; 1.) room temp. 2.) room temp.;

DOI:10.1248/cpb.39.2888

Reference yield:

S,S-dimethyl phosphorodithioate potassium salt (22608-55-5) + dimethyl sulfate (77-78-1) → O,S,S-trimethylphosphorodithoate (22608-53-3)

Guidance literature:

In acetonitrile; for 6h; Heating / reflux;

upstream raw materials:

sodium O,O-dimethyl phosphorodithioate

methyl bromide

1-(2,3-dimethylphenyl)thiourea

diazomethane

Downstream raw materials:

2-hydroxy-6,7-dimethyl-3-phenyl-4H-pyrimido[2,1-b][1,3]benzothiazol-4-one

2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-5,6-dimethyl-4H-benzo[1,4]thiazin-3-one

2-(3-Bromo-propyl)-5,6-dimethyl-4H-benzo[1,4]thiazin-3-one

2-amino-3,4-dimethylbenzenethiol

Refernces

• 1、 -. "Ion channel modulating agents". . . Retrieved 2008/06/13.
• 2、 Kajino,Mizuno,Tawada,Shibouta,Nishikawa,Meguro. "Synthesis and biological activities of new 1,4-benzothiazine derivatives". . p. 2888 - 2895. Retrieved 2007/10/02.