2,6-BIS(HYDROXYMETHYL)-1,4-DIMETHOXYBENZENE

Base Information

• Chemical Name: 2,6-BIS(HYDROXYMETHYL)-1,4-DIMETHOXYBENZENE
• CAS No.: 78840-04-7
• Molecular Formula: C10H14O4
• Molecular Weight: 198.219
• Hs Code.: 2909499000
• Mol file: 78840-04-7.mol

Synonyms:m-Xylene-α,α'-diol, 2,5-dimethoxy- (7CI);1,3-Bis(hydroxymethyl)-2,5-dimethoxybenzene;2,6-Bis(hydroxymethyl)-1,4-dimethoxybenzene;(2,5-Dimethoxybenzene-1,3-diyl)dimethanol;

Chemical Property of 2,6-BIS(HYDROXYMETHYL)-1,4-DIMETHOXYBENZENE

Chemical Property:

• Vapor Pressure: 6.12E-06mmHg at 25°C
• Melting Point: 109 °C
• Refractive Index: 1.549
• Boiling Point: 364.1 °C at 760 mmHg
• Flash Point: 174 °C
• PSA: 58.92000
• Density: 1.2 g/cm³
• LogP: 0.68840
• Solubility.: soluble in Acetone

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,6-Bis(hydroxymethyl)-1,4-dimethoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-BIS(HYDROXYMETHYL)-1,4-DIMETHOXYBENZENE

There total 4 articles about 2,6-BIS(HYDROXYMETHYL)-1,4-DIMETHOXYBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,6-bis(hydroxymethyl)-4-methoxyphenol (21893-97-0) + methyl iodide (74-88-4) → [3-(hydroxymethyl)-2,5-dimethoxyphenyl]methanol (78840-04-7)

Guidance literature:

With potassium carbonate; In acetone; for 48h; Heating;

DOI:10.1021/jm00366a004

Reference yield: 70.0%

2,6-bis(hydroxymethyl)-4-methoxyphenol (21893-97-0) + dimethyl sulfate (77-78-1) → [3-(hydroxymethyl)-2,5-dimethoxyphenyl]methanol (78840-04-7)

Guidance literature:

With potassium carbonate; In acetone; for 4h; Heating;

DOI:10.1021/jo0613378

Reference yield:

4-methoxy-phenol (150-76-5) → [3-(hydroxymethyl)-2,5-dimethoxyphenyl]methanol (78840-04-7)

Guidance literature:

Multi-step reaction with 2 steps

1: calcium oxide / H₂O

2: 70 percent / K₂CO₃ / acetone / 4 h / Heating

With potassium carbonate; calcium oxide; In water; acetone;

DOI:10.1021/jo0613378

upstream raw materials:

2,6-bis(hydroxymethyl)-4-methoxyphenol

dimethyl sulfate

methyl iodide

4-methoxy-phenol

Downstream raw materials:

{2,5-dimethoxy-3-[(4-methoxybenzyloxy)methyl]phenyl}methanol

(2,5-dimethoxy-1,3-phenylene)bis(methylene) diacetate

(1,3-di-tert-butyldimethylsilyloxymethyl)-4-iodo-2,5-dimethoxybenzene

1,3-bis(hydroxymethyl)-4-iodo-2,5-dimethoxybenzene

Refernces

• 1、 Jacques, Sylvain A.,Michaelis, Simon,Gebhardt, Bjoern,Blum, Andreas,Lebrasseur, Nathalie,Larrosa, Igor,White, Andrew J. P.,Barrett, Anthony G. M.. "Studies on the total synthesis of lactonamycin: Synthesis of the fused pentacyclic B-F ring unit". experimental part. p. 107 - 113. Retrieved 2012/01/15.
• 2、 Yamamoto, Koji,Isoue, Koichiro,Sakata, Yoshiteru,Kaneda, Takahiro. "Synthesis and Enantioselective Coloration of Optically Active Azophenolic Acerands incorporating Two 1,1'-Binaphthyl Moieties as the Chiral Centre". . p. 791 - 793. Retrieved 2007/10/02.