5-Fluoro-2-nitropyridine

Base Information

• Chemical Name: 5-Fluoro-2-nitropyridine
• CAS No.: 779345-37-8
• Molecular Formula: C5H3FN2O2
• Molecular Weight: 142.089
• Hs Code.: 2933399090
• Mol file: 779345-37-8.mol

Synonyms:5-Fluoro-2-nitropyridine;

Chemical Property of 5-Fluoro-2-nitropyridine

Chemical Property:

• Vapor Pressure: 0.046mmHg at 25°C
• Refractive Index: 1.538
• Boiling Point: 245.05 °C at 760 mmHg
• PKA: -5.01±0.22(Predicted)
• Flash Point: 102.003 °C
• PSA: 58.71000
• Density: 1.439 g/cm³
• LogP: 1.65210
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Fluoro-2-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Fluoro-2-nitropyridine

There total 1 articles about 5-Fluoro-2-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-amino-5-fluoropyridine (21717-96-4) → 5-fluoro-2-nitro-pyridine (779345-37-8)

Guidance literature:

With sulfuric acid; dihydrogen peroxide;

Reference yield: 93.0%

5-fluoro-2-nitro-pyridine (779345-37-8) + (2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidine hydrochloride → 5-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((S)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-2-nitropyridine

Guidance literature:

(2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidine hydrochloride; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

5-fluoro-2-nitro-pyridine; In N,N-dimethyl-formamide; at 80 ℃; for 16h; Inert atmosphere;

Reference yield: 90.0%

5-fluoro-2-nitro-pyridine (779345-37-8) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 4-(6-nitropyridin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester (571189-16-7)

Guidance literature:

5-fluoro-2-nitro-pyridine; With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 1h;

1-t-Butoxycarbonylpiperazine; In tetrahydrofuran; at 50 ℃; for 8h;

upstream raw materials:

2-amino-5-fluoropyridine

Downstream raw materials:

2-nitro-5-phenoxypyridine

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

4-(6-nitropyridin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester

5-((6,7-dimethoxyquinolin-4-yl)oxy)pyridine-2-amine

Refernces

• 1、 O'Brien, Alistair,Andrews, Stephen P.,Baig, Asma H.,Bortolato, Andrea,Brown, Alastair J.H.,Brown, Giles A.,Brown, Sue H.,Christopher, John A.,Congreve, Miles,Cooke, Robert M.,De Graaf, Chris,Errey, James C.,Fieldhouse, Charlotte,Jazayeri, Ali,Marshall, Fiona H.,Mason, Jonathan S.,Mobarec, Juan Carlos,Okrasa, Krzysztof,Steele, Kelly N.,Southall, Stacey M.,Teobald, Iryna,Watson, Steve P.,Weir, Malcolm. "Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure- based drug design". supporting information. . Retrieved 2019/09/30.
• 2、 -. "BICYCLIC INHIBITORS OF ALK". Page/Page column 158. . Retrieved 2012/08/07.