tert-butyl(1-(4-((3-amino-6-phenylpyridin-2-yl)amino)phenyl)cyclobutyl)carbamate

Base Information Edit

Chemical Name:tert-butyl(1-(4-((3-amino-6-phenylpyridin-2-yl)amino)phenyl)cyclobutyl)carbamate
CAS No.:1439394-30-5
Molecular Formula:C₂₆H₃₀N₄O₂
Molecular Weight:430.55
Hs Code.:
Mol file:1439394-30-5.mol

Synonyms:tert-butyl(1-(4-((3-amino-6-phenylpyridin-2-yl)amino)phenyl)cyclobutyl)carbamate

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Chemical Property of tert-butyl(1-(4-((3-amino-6-phenylpyridin-2-yl)amino)phenyl)cyclobutyl)carbamate Edit

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Technology Process of tert-butyl(1-(4-((3-amino-6-phenylpyridin-2-yl)amino)phenyl)cyclobutyl)carbamate

There total 20 articles about tert-butyl(1-(4-((3-amino-6-phenylpyridin-2-yl)amino)phenyl)cyclobutyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1439394-28-1
tert-butyl (1-(4-((3-nitro-6-phenylpyridin-2-yl)amino)phenyl)cyclobutyl)carbamate

: 1439394-30-5
tert-butyl(1-(4-((3-amino-6-phenylpyridin-2-yl)amino)phenyl)cyclobutyl)carbamate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 30 ℃; for 22h; under 2068.65 Torr;

Reference yield:

: 140-29-4
phenylacetonitrile

: 1439394-30-5
tert-butyl(1-(4-((3-amino-6-phenylpyridin-2-yl)amino)phenyl)cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: potassium hydroxide; tetrabutylammomium bromide / toluene; water / 1 h / Reflux

2: potassium nitrate; sulfuric acid / 20 °C

3: lead(IV) tetraacetate / 1.5 h / 80 °C

4: 5%-palladium/activated carbon; hydrogen / ethanol; methanol; n-heptane / 6 h / 20 °C / 2327.23 - 2585.81 Torr

5: sodium carbonate / N,N-dimethyl acetamide / 18.5 h / 100 °C

6: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 22 h / 30 °C / 2068.65 Torr

With sulfuric acid; 5%-palladium/activated carbon; palladium 10% on activated carbon; tetrabutylammomium bromide; hydrogen; lead(IV) tetraacetate; sodium carbonate; potassium nitrate; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; n-heptane; N,N-dimethyl acetamide; water; toluene;

Reference yield:

: 14377-68-5
1-phenylcyclobutanecarbonitrile

: 1439394-30-5
tert-butyl(1-(4-((3-amino-6-phenylpyridin-2-yl)amino)phenyl)cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium nitrate; sulfuric acid / 20 °C

2: lead(IV) tetraacetate / 1.5 h / 80 °C

3: 5%-palladium/activated carbon; hydrogen / ethanol; methanol; n-heptane / 6 h / 20 °C / 2327.23 - 2585.81 Torr

4: sodium carbonate / N,N-dimethyl acetamide / 18.5 h / 100 °C

5: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 22 h / 30 °C / 2068.65 Torr

With sulfuric acid; 5%-palladium/activated carbon; palladium 10% on activated carbon; hydrogen; lead(IV) tetraacetate; sodium carbonate; potassium nitrate; In tetrahydrofuran; methanol; ethanol; n-heptane; N,N-dimethyl acetamide;