Technology Process of C27H23BrO3
There total 12 articles about C27H23BrO3 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C12H18BrO4P;
With
potassium tert-butylate;
In
tetrahydrofuran;
at -78 ℃;
Inert atmosphere;
C19H16O3;
In
tetrahydrofuran;
at -78 - 25 ℃;
Inert atmosphere;
DOI:10.1002/anie.201002264
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: bromine; acetic acid / 36 h / 25 °C / Inert atmosphere
2.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 12 h / 25 °C / Inert atmosphere
3.1: trifluoroacetic acid; water / 1.5 h / 25 °C / Inert atmosphere
4.1: sodium acetate / 1 h / 140 °C / Inert atmosphere
5.1: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 24 h / 25 °C / Inert atmosphere
5.2: 0 - 25 °C
6.1: potassium tert-butylate / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere
6.2: 3 h / -78 - 25 °C
With
potassium tert-butylate; water; hydrogen; bromine; sodium acetate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; lithium chloride;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
2.1: Stobbe Condensation;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tert.-butyl lithium / diethyl ether; pentane / 8 h / -40 - -20 °C / Inert atmosphere
1.2: 12 h / 0 - 25 °C
1.3: 1 h / 0 °C
2.1: sodium tetrahydroborate / methanol / 1 h / 0 °C / Inert atmosphere
3.1: phosphorus tribromide / pyridine / diethyl ether / 4 h / 25 °C / Inert atmosphere
4.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
4.2: 12 h / 25 °C
5.1: potassium tert-butylate / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere
5.2: 3 h / -78 - 25 °C
With
sodium tetrahydroborate; potassium tert-butylate; tert.-butyl lithium; phosphorus tribromide; potassium hexamethylsilazane;
pyridine;
In
tetrahydrofuran; methanol; diethyl ether; toluene; pentane;