6-OXO-1,6-DIHYDRO-PYRAZINE-2,3-DICARBOXYLIC ACID DIAMIDE

Base Information

• Chemical Name: 6-OXO-1,6-DIHYDRO-PYRAZINE-2,3-DICARBOXYLIC ACID DIAMIDE
• CAS No.: 73403-52-8
• Molecular Formula: C₆H₆N₄O₃
• Molecular Weight: 182.139
• Mol file: 73403-52-8.mol

Synonyms:6-Oxo-1,6-dihydro-pyrazine-2,3-dicarboxylic acid diamide;2,3-pyrazinedicarboxamide, 1,6-dihydro-6-oxo-;

Chemical Property of 6-OXO-1,6-DIHYDRO-PYRAZINE-2,3-DICARBOXYLIC ACID DIAMIDE

Chemical Property:

• Refractive Index: 1.782
• PSA: 131.93000
• Density: 1.9 g/cm³
• LogP: -0.63170

Purity/Quality:

99% ^*data from raw suppliers

6-OXO-1,6-DIHYDRO-PYRAZINE-2,3-DICARBOXYLIC ACID DIAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-OXO-1,6-DIHYDRO-PYRAZINE-2,3-DICARBOXYLIC ACID DIAMIDE

There total 1 articles about 6-OXO-1,6-DIHYDRO-PYRAZINE-2,3-DICARBOXYLIC ACID DIAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

1,6-dihydro-6-oxo-2,3-pyrazinedicarbonitrile (57005-60-4) → 1,6-dihydro-6-oxo-2,3-pyrazinedicarboxamide (73403-52-8)

Guidance literature:

With hydrogenchloride; Ambient temperature;

DOI:10.1248/cpb.28.3057

Reference yield:

1,6-dihydro-6-oxo-2,3-pyrazinedicarboxamide (73403-52-8) → methyl 1,6-dihydro-6-oxo-2-pyrazinecarboxylate (13924-98-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) 10percent NaOH; 2.) SOCl₂ / 1.) reflux, 5 h; 2.) reflux, 3 h

2: 5 h / Heating

3: 56 percent / nitrobenzene / 7 h / 180 - 190 °C

With sodium hydroxide; thionyl chloride; nitrobenzene;

DOI:10.1248/cpb.28.3057

Reference yield:

1,6-dihydro-6-oxo-2,3-pyrazinedicarboxamide (73403-52-8) → 1H-furo<3,4-b>pyrazine-2,5,7-trione (73403-50-6)

Guidance literature:

With sodium hydroxide; thionyl chloride; Yield given. Multistep reaction; 1.) reflux, 5 h; 2.) reflux, 3 h;

DOI:10.1248/cpb.28.3057

upstream raw materials:

1,6-dihydro-6-oxo-2,3-pyrazinedicarbonitrile

Downstream raw materials:

1H-furo<3,4-b>pyrazine-2,5,7-trione

methyl 1,6-dihydro-6-oxo-2-pyrazinecarboxylate

Refernces