5-METHOXY-2,3-DIHYDRO-1H-INDEN-2-AMINE

Base Information

• Chemical Name: 5-METHOXY-2,3-DIHYDRO-1H-INDEN-2-AMINE
• CAS No.: 73305-09-6
• Molecular Formula: C10H13 N O
• Molecular Weight: 163.219
• Hs Code.: 2922199090
• Mol file: 73305-09-6.mol

Synonyms:2-Amino-5-methoxyindan;5-Methoxy-2,3-dihydro-1H-inden-2-amine; 5-Methoxy-2-indanamine;5-Methoxyindan-2-ylamine

Chemical Property of 5-METHOXY-2,3-DIHYDRO-1H-INDEN-2-AMINE

Chemical Property:

• Boiling Point: 277.6±40.0 °C(Predicted)
• PKA: 9.33±0.20(Predicted)
• PSA: 35.25000
• Density: 1.087±0.06 g/cm3(Predicted)
• LogP: 1.82140

Purity/Quality:

99% ^*data from raw suppliers

5-Methoxy-2,3-dihydro-1H-inden-2-amine hydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-METHOXY-2,3-DIHYDRO-1H-INDEN-2-AMINE

There total 9 articles about 5-METHOXY-2,3-DIHYDRO-1H-INDEN-2-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-(methyloxy)-2,3-dihydro-1H-inden-2-amine hydrochloride (81593-54-6) → (±)-2-amino-5-methoxyindane (73305-09-6)

Guidance literature:

With sodium hydroxide; In methanol; water; at 0 - 25 ℃; for 3h;

DOI:10.1016/j.tetasy.2016.04.005

Reference yield: 37.0%

5-methoxy-indan-1,2-dione 2-oxime (7235-36-1) → (±)-2-amino-5-methoxyindane (73305-09-6)

Guidance literature:

5-methoxy-indan-1,2-dione 2-oxime; With sulfuric acid; hydrogen; palladium 10% on activated carbon; In acetic acid; for 18h; under 3102.97 Torr;

With sodium hydroxide; In water; at 0 ℃; pH=10;

Reference yield:

2-(hydroxyimino)-6-methoxy-2,3-dihydro-1H-inden-1-one (24077-98-3) → (±)-2-amino-5-methoxyindane (73305-09-6)

Guidance literature:

With sulfuric acid; palladium-carbon; palladium(II) chloride; In acetic acid;

upstream raw materials:

2-(hydroxyimino)-6-methoxy-2,3-dihydro-1H-inden-1-one

2-amino-6-methoxy-indan-1-ol; hydrochloride

5-methoxy-indan-1,2-dione 2-oxime

5-methoxy-1-indanone

Downstream raw materials:

5-(methyloxy)-2,3-dihydro-1H-inden-2-amine hydrochloride

2-(5-methoxyindane-2-yl)isoindole-1,3,dione

Refernces

• 1、 -. "INDOLE AHR INHIBITORS AND USES THEREOF". . . Retrieved 2018/11/22.
• 2、 -. "SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS". Page/Page column 26. . Retrieved 2008/12/04.