6-chloro-2-phenyl-1,3-benzothiazole

Base Information

• Chemical Name: 6-chloro-2-phenyl-1,3-benzothiazole
• CAS No.: 7466-32-2
• Molecular Formula: C13H8 Cl N S
• Molecular Weight: 245.732
• Mol file: 7466-32-2.mol

Synonyms:NSC 402599

Chemical Property of 6-chloro-2-phenyl-1,3-benzothiazole

Chemical Property:

• Vapor Pressure: 6.58E-06mmHg at 25°C
• Boiling Point: 389°C at 760 mmHg
• Flash Point: 189.1°C
• Density: 1.339g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-chloro-2-phenyl-1,3-benzothiazole

There total 41 articles about 6-chloro-2-phenyl-1,3-benzothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-(4-chlorophenyl)thiobenzamide (5310-28-1) → 6-chloro-2-phenylbenzo[d]thiazole (7466-32-2)

Guidance literature:

With dmap; Co^III(dimethylglyoximate)₂(4-NMe₂-C₅H₄N)Cl; [Ni(2,2'-bipyridine)₃][PF₆]₂; sodium glycinate; In acetonitrile; at 20 ℃; for 12h; Reagent/catalyst; Inert atmosphere; Irradiation; Schlenk technique;

DOI:10.1021/jacs.5b05665

Reference yield: 96.0%

N-(2-bromo-4-chlorophenyl)benzothioamide → 6-chloro-2-phenylbenzo[d]thiazole (7466-32-2)

Guidance literature:

With sodium phosphate; In dimethyl sulfoxide; at 20 ℃; for 10h; Inert atmosphere; Irradiation;

DOI:10.1021/acs.orglett.1c00235

Reference yield: 92.0%

2-amino-5-chlorobenzenethiol (23474-98-8) + benzaldehyde (100-52-7) → 6-chloro-2-phenylbenzo[d]thiazole (7466-32-2)

Guidance literature:

With aluminum potassium sulfate dodecahydrate; In water; at 20 ℃; for 1.16667h;

DOI:10.1071/CH08122

upstream raw materials:

N-(4-chlorophenyl)thiobenzamide

benzaldehyde

6-chloro-3H-benzo[d][1,2,3]dithiazole 2-oxide

benzoyl chloride

Downstream raw materials:

2-([1,1':3',1''-terphenyl]-2'-yl)-6-chlorobenzo[d]thiazole

6-chloro-2-(4,4''-dichloro-[1,1':3',1''-terphenyl]-2'-yl)benzo[d]thiazole

6-chloro-2-(4,4''-dimethyl-[1,1':3',1''-terphenyl]-2'-yl)benzo[d]thiazole

2-(3-nitrophenyl)-6-chlorobenzothiazole

Refernces

• 1、 Cai, Mingzhong,Hao, Wenyan,Huang, Wencheng,Ye, Qian. "Recyclable copper-catalyzed cyclization of o-haloanilides and metal sulfides: An efficient and practical access to substituted benzothiazoles". . . Retrieved 2022/01/19.
• 2、 Bai, Jin,Yan, Sijia,Zhang, Zhuxia,Guo, Zhen,Zhou, Cong-Ying. "Visible-Light Carbon Nitride-Catalyzed Aerobic Cyclization of Thiobenzanilides under Ambient Air Conditions". supporting information. p. 4843 - 4848. Retrieved 2021/06/28.