2-(Aminomethyl)-4-chloroaniline

Base Information

• Chemical Name: 2-(Aminomethyl)-4-chloroaniline
• CAS No.: 771572-99-7
• Molecular Formula: C7H9ClN2
• Molecular Weight: 140.16
• Hs Code.: 2921590090
• Mol file: 771572-99-7.mol

Synonyms:2-Aminomethyl-4-fluorophenylamine;benzenemethanamine, 2-amino-5-fluoro-;2-(aminomethyl)-4-fluoro-aniline;

Chemical Property of 2-(Aminomethyl)-4-chloroaniline

Chemical Property:

• Boiling Point: 263.872 °C at 760 mmHg
• PKA: 9.33±0.10(Predicted)
• Flash Point: 116.847 °C
• PSA: 52.04000
• Density: 1.209 g/cm³
• LogP: 2.14810

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Aminomethyl)-4-fluoroaniline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Aminomethyl)-4-chloroaniline

There total 1 articles about 2-(Aminomethyl)-4-chloroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

2-cyano-4-fluoroaniline (61272-77-3) → 2-(aminomethyl)-4-fluoroaniline (771572-99-7)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 20 ℃; for 44h;

DOI:10.1021/jacs.7b03131

Reference yield: 78.0%

2-(aminomethyl)-4-fluoroaniline (771572-99-7) + 4-chlorobenzaldehyde (104-88-1) → 2-(4-chlorophenyl)-5-fluoroquinazoline (1222094-46-3)

Guidance literature:

With [(p-cymene)Ru(66’- (0Η)2bpy)(Η2Ο)][OTf]; In water; at 130 ℃; for 12h;

Reference yield: 77.0%

2-(aminomethyl)-4-fluoroaniline (771572-99-7) + benzonitrile (100-47-0) → 6-fluoro-2-phenylquinazoline (1399327-71-9)

Guidance literature:

With nicotinic acid; In dimethyl sulfoxide; at 110 ℃; for 24h;

DOI:10.1002/ejoc.201901651

upstream raw materials:

2-cyano-4-fluoroaniline

Downstream raw materials:

6-fluoro-2-phenylquinazoline

2-(4-chlorophenyl)-5-fluoroquinazoline

6-fluoro-2-(4-chlorophenyl)quinazoline

Refernces

• 1、 Taylor, Nicholas J.,Emer, Enrico,Preshlock, Sean,Schedler, Michael,Tredwell, Matthew,Verhoog, Stefan,Mercier, Joel,Genicot, Christophe,Gouverneur, Véronique. "Derisking the Cu-Mediated 18F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands". supporting information. p. 8267 - 8276. Retrieved 2017/06/27.