3-(4-chlorobenzoyl)pentane-2,4-dione

Base Information

• Chemical Name: 3-(4-chlorobenzoyl)pentane-2,4-dione
• CAS No.: 165684-80-0
• Molecular Formula: C₁₂H₁₁ClO₃
• Molecular Weight: 238.671
• Mol file: 165684-80-0.mol

Synonyms:3-(4-chlorobenzoyl)pentane-2,4-dione

Chemical Property of 3-(4-chlorobenzoyl)pentane-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-chlorobenzoyl)pentane-2,4-dione

There total 4 articles about 3-(4-chlorobenzoyl)pentane-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-chloro-benzoyl chloride (122-01-0) + acetylacetone (123-54-6,81235-32-7) → 3-(4-chlorobenzoyl)pentane-2,4-dione (165684-80-0)

Guidance literature:

With samarium(III) chloride; triethylamine; In toluene; at 20 ℃; for 0.5h;

DOI:10.1021/ol701961z

Reference yield:

bromochlorobenzene (106-39-8) + 9-methyl-9H-fluorene-9-carbonyl chloride (82102-37-2) + acetylacetone (123-54-6,81235-32-7) → 3-(4-chlorobenzoyl)pentane-2,4-dione (165684-80-0)

Guidance literature:

bromochlorobenzene; acetylacetone; With dichloro(1,5-cyclooctadiene)palladium(II); triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; magnesium chloride; In 1,4-dioxane; at 80 ℃; Glovebox; Inert atmosphere;

9-methyl-9H-fluorene-9-carbonyl chloride; With dichloro(1,5-cyclooctadiene)palladium(II); N-Methyldicyclohexylamine; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; at 80 ℃; Glovebox; Inert atmosphere;

In 1,4-dioxane; at 80 ℃; for 18h;

DOI:10.1002/chem.201303872

Reference yield:

Ketene (463-51-4) + 1-(4'-chlorophenyl)-1,3-butanedione (6302-55-2) → 3-(4-chlorobenzoyl)pentane-2,4-dione (165684-80-0)

Guidance literature:

upstream raw materials:

Ketene

1-(4'-chlorophenyl)-1,3-butanedione

4-chloro-benzoyl chloride

acetylacetone

Downstream raw materials:

1-(4'-chlorophenyl)-1,3-butanedione

1-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)propane-1,3-dione

Refernces

• 1、 Shen, Quansheng,Huang, Wen,Wang, Jialiang,Zhou, Xigeng. "SmCl3-catalyzed C-acylation of 1,3-dicarbonyl compounds and malononitrile". . p. 4491 - 4494. Retrieved 2008/03/12.