4-[(4-NITROPHENYL)SULFONYL]MORPHOLINE

Base Information

• Chemical Name: 4-[(4-NITROPHENYL)SULFONYL]MORPHOLINE
• CAS No.: 1024-30-2
• Molecular Formula: C10H12N2O5S
• Molecular Weight: 272.282
• Hs Code.: 2934999090
• Mol file: 1024-30-2.mol

Synonyms:Morpholine,4-[(p-nitrophenyl)sulfonyl]- (7CI,8CI);NSC 38560;4-[(4-Nitrophenyl)sulfonyl]morpholine;N-(4-Nitrophenylsulfonyl)morpholine;

Chemical Property of 4-[(4-NITROPHENYL)SULFONYL]MORPHOLINE

Chemical Property:

• Vapor Pressure: 1.38E-08mmHg at 25°C
• Melting Point: 173 °C
• Refractive Index: 1.594
• Boiling Point: 458.4 °C at 760 mmHg
• PKA: -8.69±0.20(Predicted)
• Flash Point: 231 °C
• PSA: 100.81000
• Density: 1.45 g/cm³
• LogP: 2.15760
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-[(4-Nitrophenyl)sulfonyl]morpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[(4-NITROPHENYL)SULFONYL]MORPHOLINE

There total 13 articles about 4-[(4-NITROPHENYL)SULFONYL]MORPHOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

morpholine (110-91-8,99108-56-2) + 4-Nitrobenzenesulfonyl chloride (98-74-8) → 4-(4-nitrobenzenesulfonyl)morpholine (1024-30-2)

Guidance literature:

for 12h; Alkaline conditions;

DOI:10.1007/s00044-021-02827-1

Reference yield: 87.0%

morpholine (110-91-8,99108-56-2) + 4-nitrobenzenesulfonohydrazide (2937-05-5) → 4-(4-nitrobenzenesulfonyl)morpholine (1024-30-2)

Guidance literature:

With tert.-butylhydroperoxide; iodine; In decane; 1,2-dichloro-ethane; at 20 ℃; for 1h;

DOI:10.1039/c5ob02075a

Reference yield: 81.0%

morpholine (110-91-8,99108-56-2) + 4-nitrobenzenediazonium tetrafluoroborate (456-27-9) → 4-(4-nitrobenzenesulfonyl)morpholine (1024-30-2)

Guidance literature:

4-nitrobenzenediazonium tetrafluoroborate; With 1,4-diazabicyclo[2.2.2]octane-triethylenediamine-bis(sulfur dioxide); benzotriazol-1-ol; In 1,2-dichloro-ethane; at 60 ℃; for 1h; Inert atmosphere;

morpholine; With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/adsc.201700501

upstream raw materials:

morpholine

4-Nitrobenzenesulfonyl chloride

N-(p-nitrophenylthio)morpholine

4-oxa-1,7-heptanediyl bis(diphenylphosphinite)

Downstream raw materials:

4-(morpholinosulfonyl)aniline

N-(4-(morpholinosulfonyl)phenyl)-3-oxobenzo[d]isothiazole-2(3H)-carboxamid

N-[4-(isocyanato)phenylsulfonyl]morpholine

4-cyano-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole-2-carboxylic acid [2-cyclohex-1-enyl-4-(morpholine-4-sulfonyl)-phenyl]-amide

Refernces

• 1、 Chung, Sohyun,Kim, Jinho. "Cu-catalyzed aerobic oxidative synthesis of sulfonamides from sulfonyl hydrazides and amines". . p. 792 - 795. Retrieved 2019.
• 2、 Finiuk, Nataliya,Manko, Nazar,Obushak, Mykola,Palchykov, Vitalii,Pokhodylo, Nazariy,Stoika, Rostyslav. "Antimicrobial action of arylsulfonamides bearing (aza)norbornane and related motifs: evaluation of new promising anti-MRSA agents". . p. 284 - 292. Retrieved 2022/01/12.
• 3、 Baucom, Kyle D.,Brown, Derek B.,Caille, Seb,Murray, James I.,Quasdorf, Kyle,Silva Elipe, Maria V.. "Ipso Nitration of Aryl Boronic Acids Using Fuming Nitric Acid". supporting information. . Retrieved 2021/06/30.