2-chloro-4-(4-methoxyphenyl)thiophene

Base Information

• Chemical Name: 2-chloro-4-(4-methoxyphenyl)thiophene
• CAS No.: 54095-29-3
• Molecular Formula: C₁₁H₉ClOS
• Molecular Weight: 224.711
• Mol file: 54095-29-3.mol

Synonyms:2-chloro-4-(p-methoxyphenyl)thiophene

Chemical Property of 2-chloro-4-(4-methoxyphenyl)thiophene

Chemical Property:

Purity/Quality:

2-CHLORO-4-(4-METHOXYPHENYL)THIOPHENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-4-(4-methoxyphenyl)thiophene

There total 5 articles about 2-chloro-4-(4-methoxyphenyl)thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

3-(4-methoxy-phenyl)-thiophene (82437-75-0) → 2-chloro-4-(p-methoxyphenyl)thiophene (54095-29-3) + 2-chloro-3-(p-methoxyphenyl)thiophene (158837-25-3)

Guidance literature:

With sulfuryl dichloride; In tetrachloromethane; for 8h; Heating;

DOI:10.1246/bcsj.67.2187

Reference yield: 34.0%

2,5-diclorothiophene (3172-52-9,173777-89-4) + methoxybenzene (100-66-3) → 2-chloro-4-(p-methoxyphenyl)thiophene (54095-29-3) + 2,4-bis(4-methoxyphenyl)thiophene (62497-30-7)

Guidance literature:

With aluminium trichloride; In dichloromethane; 5 deg C_., 30 min., than RT, 1 h;

DOI:10.1246/bcsj.61.3779

Reference yield: 34.0%

2,5-diclorothiophene (3172-52-9,173777-89-4) + methoxybenzene (100-66-3) → 2-chloro-4-(p-methoxyphenyl)thiophene (54095-29-3) + 1-sec-butyl-4-methoxybenzene (4917-90-2) + 2,4-bis(4-methoxyphenyl)thiophene (62497-30-7) + chlorobis(p-methoxyphenyl)bithienyl

Guidance literature:

With aluminium trichloride; In dichloromethane; 5 deg C, 30 m9n., than RT;

DOI:10.1246/bcsj.61.3779

upstream raw materials:

2,5-diclorothiophene

methoxybenzene

3-(4-methoxy-phenyl)-thiophene

Downstream raw materials:

5-chloro-2-iodo-3-(p-methoxyphenyl)thiophene

2-chloro-4-(p-methoxyphenyl)-5-phenylthiophene

3,4'-bis(p-methoxyphenyl)-2,2'-bithienyl

biphenyl

Refernces

• 1、 Sone, Tyo,Inoue, Manabu,Sato, Kazuaki. "A New and Simple Route to 3-Arylthiophenes". . p. 3779 - 3781. Retrieved 2007/10/02.