Cathinone hydrochloride

Base Information

• Chemical Name: Cathinone hydrochloride
• CAS No.: 72739-14-1
• Molecular Formula: C9H11 N O . Cl H
• Molecular Weight: 185.653
• European Community (EC) Number: 804-103-9
• UNII: 272NNG64V6
• DSSTox Substance ID: DTXSID8048866
• Wikidata: Q27254154
• ChEMBL ID: CHEMBL3182836
• Mol file: 72739-14-1.mol

Synonyms:(-)-alpha-amino-propiophenone;2-amino-1-phenyl-1-propanone;2-aminopropiophenone;alpha-aminopropiophenone;cathinine;cathinone;cathinone hydrochloride;cathinone hydrochloride, (+-)-isomer;cathinone hydrochloride, (R)-isomer;cathinone hydrochloride, (S)-isomer;cathinone, (+-)-isomer;cathinone, (S)-isomer

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Cathinone hydrochloride

Chemical Property:

• Flash Point: 9℃
• PSA: 43.09000
• LogP: 2.71880
• Storage Temp.: ?20°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 185.0607417
• Heavy Atom Count: 12
• Complexity: 139

Purity/Quality:

Safty Information:

• Pictogram(s): F,T
• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 7-16-36/37-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(=O)C1=CC=CC=C1)N.Cl
• Isomeric SMILES: C[C@@H](C(=O)C1=CC=CC=C1)N.Cl
• Uses: Psychoactive alkaloid found in the leaves of the khat plant, Catha edulis Forsk., Celastraceae. Controlled substance (stimulant).

Technology Process of Cathinone hydrochloride

There total 16 articles about Cathinone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(S)-N-(1-Methyl-2-oxo-2-phenylethyl)carbamidsaeure-(tert-butyl)ester (79821-73-1) → (-)-Cathinone hydrochloride (72739-14-1)

Guidance literature:

With hydrogenchloride; In ethyl acetate; for 0.5h; Ambient temperature;

DOI:10.1021/jo00105a060

Reference yield: 60.0%

(-)-N-formyl-α-aminopropiophenone (81626-23-5) → (-)-Cathinone hydrochloride (72739-14-1)

Guidance literature:

With hydrogenchloride; at 40 ℃;

DOI:10.1021/jo00134a026

Reference yield:

(S)-2-((4-methoxyphenyl)amino)-1-phenylpropan-1-one → (-)-Cathinone hydrochloride (72739-14-1)

Guidance literature:

With trichloroisocyanuric acid; sulfuric acid; In water; acetonitrile; at 20 ℃; for 16h;

DOI:10.1021/jacs.0c07210

upstream raw materials:

(-)-N-formyl-α-aminopropiophenone

(S)-N-(1-Methyl-2-oxo-2-phenylethyl)carbamidsaeure-(tert-butyl)ester

(-)-(1R,2S)-2-Azido-1-(tert-butyldimethylsiloxy)-1-phenylpropane

bromobenzene

Downstream raw materials:

(S)-N-(1-Methyl-2-oxo-2-phenylethyl)carbamidsaeure-(tert-butyl)ester

cathinone

(R)-β‐ketoamphetamine

Refernces

• 1、 Guo, Wengang,Li, Pingfan,Luo, Yuzheng,Sun, Jianwei,Sung, Herman H.-Y.,Williams, Ian D.. "Chiral Phosphoric Acid Catalyzed Enantioselective Synthesis of α-Tertiary Amino Ketones from Sulfonium Ylides". . p. 14384 - 14390. Retrieved 2020/09/15.
• 2、 Hwang, Gweon Il,Chung, Jae-Ho,Lee, Won Koo. "An efficient synthesis of both enantiomers of Cathinone by regioselective reductive ring opening of substituted aziridines". . p. 12111 - 12116. Retrieved 2007/10/03.