GLY-7-AMINO-4-METHYLCOUMARIN

Base Information

• Chemical Name: GLY-7-AMINO-4-METHYLCOUMARIN
• CAS No.: 77471-42-2
• Molecular Formula: C₁₂H₁₂N₂O₃
• Molecular Weight: 232.239
• Hs Code.: 2932209090
• Mol file: 77471-42-2.mol

Synonyms:H-GLY-AMC;L-GLY-AMC;L-GLY-7-AMINO-4-METHYLCOUMARIN;GLYCINE 7-AMIDO-4-METHYLCOUMARIN;GLY-7-AMINO-4-METHYLCOUMARIN

Chemical Property of GLY-7-AMINO-4-METHYLCOUMARIN

Chemical Property:

• Boiling Point: 495.2±45.0 °C(Predicted)
• PKA: 12.77±0.20(Predicted)
• PSA: 88.82000
• Density: 1.351±0.06 g/cm3(Predicted)
• LogP: 2.34840
• Storage Temp.: Store at 0-5°C

Purity/Quality:

99%+, ^*data from raw suppliers

L-Gly-7-amino-4-methylcoumarin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of GLY-7-AMINO-4-METHYLCOUMARIN

There total 1 articles about GLY-7-AMINO-4-METHYLCOUMARIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Boc-Gly-AMC → L-Gly-AMC (77471-42-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 1h;

DOI:10.1007/s11426-013-4885-x

Reference yield:

L-Gly-AMC (77471-42-2) + N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → C25H25N3O7

Guidance literature:

Multi-step reaction with 2 steps

1.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 16 h / 20 °C

2.1: trifluoroacetic acid / water / 2 h / 20 °C

2.2: 20 h / 20 °C

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2015.04.064

Refernces