2,7-dichlorofluorescein

Base Information

• Chemical Name: 2,7-dichlorofluorescein
• CAS No.: 18362-80-6
• Molecular Formula: C₂₀H₁₀Cl₂O₅
• Molecular Weight: 401.202
• Mol file: 18362-80-6.mol

Synonyms:2,7-dichlorofluorescein

Chemical Property of 2,7-dichlorofluorescein

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,7-dichlorofluorescein

There total 17 articles about 2,7-dichlorofluorescein which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

→ 2,7-dichlorofluorescein (18362-80-6)

Guidance literature:

With methanesulfonic acid; at 100 ℃; for 24h;

Reference yield: 90.0%

phthalic anhydride (85-44-9) + 4-Chlororesorcinol (95-88-5) → 2,7-dichlorofluorescein (18362-80-6)

Guidance literature:

With methanesulfonic acid; at 60 ℃; for 15h;

DOI:10.1039/c4ob02256d

Reference yield: 37.0%

6-(but-3-en-1-yloxy)-2,7-dichloro-9-(2-(hydroxymethyl)phenyl)-3Hxanthen-3-one (1181325-08-5) → 2,7-dichlorofluorescein (18362-80-6)

Guidance literature:

6-(but-3-en-1-yloxy)-2,7-dichloro-9-(2-(hydroxymethyl)phenyl)-3Hxanthen-3-one; With ozone; In water; acetone; at 0 ℃; for 0.25h; Inert atmosphere;

With potassium iodide; In water; acetone; for 1h; Mechanism; Inert atmosphere;

DOI:10.1039/c4cc08244c

upstream raw materials:

2-(3,6-diacetyloxy-2,7-dichloro-9H-xanthen-9-yl)benzoic acid

bis(2,4-dinitrobenzenesulfonyl)-2',7'-dichlorofluorescein

2-(2,7-dichloro-3,6-dihydroxy-9H-xanthen-9-yl)benzoic acid

2',7'-dichlorofluorescein

Downstream raw materials:

2-(2,7-Dichloro-6-hydroxy-3-oxo-3H-xanthen-9-yl)-benzoic acid (2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester

6-(but-3-en-1-yloxy)-2,7-dichloro-9-(2-(hydroxymethyl)phenyl)-3Hxanthen-3-one

9-(o-carboxyphenyl)-2,7-dichloro-4,5-bis[bis(2-pyridylmethyl)-aminomethyl]-6-hydroxy-3-xanthanone

2-(2,7-dichloro-3,6-dihydroxy-9H-xanthen-9-yl)benzoic acid

Refernces

• 1、 Bai, Xiaoyu,Huang, Yueyang,Lu, Mingyang,Yang, Dan. "HKOH-1: A Highly Sensitive and Selective Fluorescent Probe for Detecting Endogenous Hydroxyl Radicals in Living Cells". . p. 12873 - 12877. Retrieved 2017.
• 2、 Mihalyi, Agnes,Jamshidi, Shirin,Slikas, Justinas,Bugg, Timothy D.H.. "Identification of novel inhibitors of phospho-MurNAc-pentapeptide translocase MraY from library screening: Isoquinoline alkaloid michellamine B and xanthene dye phloxine B". . p. 4566 - 4571. Retrieved 2014.
• 3、 Zhao, Hao,Xu, Xiushang,Zhou, Long,Hu, Yunbin,Huang, Yiming,Narita, Akimitsu. "Water-Soluble Nanoparticles with Twisted Double [7]Carbohelicene for Lysosome-Targeted Cancer Photodynamic Therapy". . . Retrieved 2021/11/10.
• 4、 -. "Fat mass and obesity-associated protein (FTO) inhibitors prepared from 9-(2-carboxyphenyl) xanthene compounds and therapeutic effects thereof". Paragraph 0055-0058; 0065-0067. . Retrieved 2020/07/13.