N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^ε-carbobenzoxy-L-lysine methyl ester

Base Information

• Chemical Name: N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^ε-carbobenzoxy-L-lysine methyl ester
• CAS No.: 56892-79-6
• Molecular Formula: C₃₀H₃₅N₉O₅
• Molecular Weight: 601.665
• Mol file: 56892-79-6.mol

Synonyms:N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^ε-carbobenzoxy-L-lysine methyl ester

Chemical Property of N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^ε-carbobenzoxy-L-lysine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^ε-carbobenzoxy-L-lysine methyl ester

There total 2 articles about N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^ε-carbobenzoxy-L-lysine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid (19741-14-1) → Nα-(4-amino-4-deoxy-N10-methylpteroyl)-Nε-carbobenzoxy-L-lysine methyl ester (56892-79-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / dimethylformamide / 3.5 h / Ambient temperature

2: Et₃N / dimethylformamide / 72 h / Ambient temperature

With triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm00350a015

Reference yield:

methotrexate sodium salt (7532-09-4) → Nα-(4-amino-4-deoxy-N10-methylpteroyl)-Nε-carbobenzoxy-L-lysine methyl ester (56892-79-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / 1 N NaOAc, ZnCl₂ / 37 °C

2: Et₃N / dimethylformamide / 3.5 h / Ambient temperature

3: Et₃N / dimethylformamide / 72 h / Ambient temperature

With sodium acetate; triethylamine; zinc(II) chloride; In N,N-dimethyl-formamide;

DOI:10.1021/jm00350a015

Reference yield: 91.0%

Nα-(4-amino-4-deoxy-N10-methylpteroyl)-Nε-carbobenzoxy-L-lysine methyl ester (56892-79-6) → Nα-(4-amino-4-deoxy-N10-methylpteroyl)-L-lysine (80407-56-3,246224-40-8)

Guidance literature:

With hydrogen bromide; trifluoroacetic acid; for 0.0833333h; Heating;

DOI:10.1021/jm00350a015

upstream raw materials:

4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid

methotrexate sodium salt

Downstream raw materials:

N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^ε-carbobenzoxy-L-lysine

N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-L-lysine

N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^ε-(iodoacetyl)-L-lysine

Refernces