1H-Imidazole-4-carbothioamide,5-hydroxy-(9CI)

Base Information

• Chemical Name: 1H-Imidazole-4-carbothioamide,5-hydroxy-(9CI)
• CAS No.: 71644-33-2
• Molecular Formula: C₄H₅N₃OS
• Molecular Weight: 143.169
• Mol file: 71644-33-2.mol

Synonyms:1H-Imidazole-4-carbothioamide,5-hydroxy-(9CI)

Chemical Property of 1H-Imidazole-4-carbothioamide,5-hydroxy-(9CI)

Chemical Property:

• PSA: 107.02000
• LogP: 0.44980

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Imidazole-4-carbothioamide,5-hydroxy-(9CI)

There total 2 articles about 1H-Imidazole-4-carbothioamide,5-hydroxy-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

5-hydroxy-1H-imidazole-4-carboxamide (56973-26-3) → 4(5)-Hydroxyimidazole-4(5)-carbothioamide (71644-33-2)

Guidance literature:

With tetraphosphorus decasulfide; In 1,4-dioxane; for 4h; Heating;

DOI:10.1007/BF00758536

Reference yield:

→ 4(5)-Hydroxyimidazole-4(5)-carbothioamide (71644-33-2)

Guidance literature:

5(4)-Hydroxyimidazol-4(5)-carboxamid u. P4S10;

DOI:10.1007/BF00473570

Reference yield: 15.0%

4(5)-Hydroxyimidazole-4(5)-carbothioamide (71644-33-2) → 5(4)-Hydroxyimidazole-4(5)-carbonitrile (79713-03-4)

Guidance literature:

With methylamine; mercury dichloride; In ethanol; at 30 ℃; for 0.5h;

DOI:10.1007/BF00758536

upstream raw materials:

5-hydroxy-1H-imidazole-4-carboxamide

Downstream raw materials:

5(4)-Hydroxyimidazole-4(5)-carbonitrile

Refernces

• 1、 Bakulev, V. A.,Mokrushin, V. S.,Polishchuk, N. V.,Zhuravleva, I. A.,Anoshina, G. M.,et al.. "SYNTHESIS OF ANALOGS OF 5(4)-AMINOIMIDAZOLE-4(5)-CARBOXAMIDE AND PURINES. X. SYNTHESIS AND STUDY OF PROPERTIES OF NEW ANALOGS OF BREDININ AGLYCONE". . p. 498 - 500. Retrieved 2007/10/02.