1-Methyl-cyclobutylamine

Base Information

• Chemical Name: 1-Methyl-cyclobutylamine
• CAS No.: 40571-47-9
• Molecular Formula: C5H11N
• Molecular Weight: 85.149
• Hs Code.: 2921300090
• Mol file: 40571-47-9.mol

Synonyms:Cyclobutylamine,1-methyl- (6CI);1-Methyl-1-cyclobutylamine;1-Methylcyclobutylamine;

Chemical Property of 1-Methyl-cyclobutylamine

Chemical Property:

• Boiling Point: 92.7 °C at 760 mmHg
• Flash Point: -9℃
• PSA: 26.02000
• Density: 0.878g/cm³
• LogP: 1.58800

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Methylcyclobutanamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Methylcyclobutanamine is a useful reagent for acid catalyzed rearrangement and in ritter reactions.

Technology Process of 1-Methyl-cyclobutylamine

There total 3 articles about 1-Methyl-cyclobutylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methylidenecyclobutane (1120-56-5) + sodium cyanide (143-33-9,25596-52-5) → 1-methylcyclobutan-1-amine (40571-47-9)

Guidance literature:

Multistep reaction; (i) AcOH, aq. H₂SO₄, (ii) aq. NaOH;

DOI:10.1021/ja01473a028

Reference yield:

methylidenecyclobutane (1120-56-5) + acetonitrile (75-05-8,26809-02-9) → 1-methylcyclobutan-1-amine (40571-47-9)

Guidance literature:

Multistep reaction; (i) AcOH, aq. H₂SO₄, (ii) aq. KOH, ethane-1,2-diol;

DOI:10.1021/ja01473a028

Reference yield:

1-methylcyclobutanol (20117-47-9) + potassium cyanide (151-50-8) → 1-methylcyclobutan-1-amine (40571-47-9)

Guidance literature:

With dibutyl ether; sulfuric acid; und Erhitzen des Reaktionsprodukts mit wss. HCl;

upstream raw materials:

1-methylcyclobutanol

potassium cyanide

methylidenecyclobutane

sodium cyanide

Downstream raw materials:

N-[(5Z)-4-butyl-2-(1-methylcyclobutyl)-isothiazol-5(2H)-ylidene]-5-chloro-2-methoxybenzamide

1-(1-methylcyclobutyl)-4-phenyl-1H-imidazole

1-(1-methylcyclobutyl)-5-phenyl-1H-imidazole

3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methyl-N-(1-methylcyclobutyl)benzamide