[1-(AMINOMETHYL)CYCLOPROPYL]METHANOL

Base Information

• Chemical Name: [1-(AMINOMETHYL)CYCLOPROPYL]METHANOL
• CAS No.: 45434-02-4
• Molecular Formula: C5H11NO
• Molecular Weight: 101.148
• Hs Code.: 2922199090
• Mol file: 45434-02-4.mol

Synonyms:Cyclopropanemethanol, 1-(aminomethyl)-;

Chemical Property of [1-(AMINOMETHYL)CYCLOPROPYL]METHANOL

Chemical Property:

• Vapor Pressure: 0.437mmHg at 25°C
• Refractive Index: 1.506
• Boiling Point: 171.746 °C at 760 mmHg
• PKA: 15.10±0.10(Predicted)
• Flash Point: 57.67 °C
• PSA: 46.25000
• Density: 1.065 g/cm³
• LogP: 0.41790

Purity/Quality:

99% ^*data from raw suppliers

[1-?(Aminomethyl)?cyclopropyl]?methanol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: [1-?(Aminomethyl)?cyclopropyl]?methanol is a reagent used in the synthesis of novel CB1 antagonists.

Technology Process of [1-(AMINOMETHYL)CYCLOPROPYL]METHANOL

There total 4 articles about [1-(AMINOMETHYL)CYCLOPROPYL]METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.6%

1-(aminocarbonyl)-1-cyclopropanecarboxylic acid methyl ester (6914-80-3) → (1-(aminomethyl)cyclopropyl)methanol (45434-02-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 6h;

DOI:10.1021/jm050756e

Reference yield:

ethyl 1-(cyanomethyl)cyclopropanecarboxylate (3697-69-6) → (1-(aminomethyl)cyclopropyl)methanol (45434-02-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 4h;

Reference yield:

1-hydroxymethyl-cyclopropanecarbonitrile (98730-77-9) → (1-(aminomethyl)cyclopropyl)methanol (45434-02-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 45 ℃; for 18h;

upstream raw materials:

1-carbethoxy-1-cyanocyclopropane

1-(aminocarbonyl)-1-cyclopropanecarboxylic acid methyl ester

ethyl 1-(cyanomethyl)cyclopropanecarboxylate

1-hydroxymethyl-cyclopropanecarbonitrile

Downstream raw materials:

{(1S,2S,4S)-1-{(S)-2-[4-fluoro-3-(3-methoxy-propoxy)-benzyl]-3-methyl-butyl}-2-hydroxy-4-[(1-hydroxymethyl-cyclopropylmethyl)-carbamoyl]-5-methyl-hexyl}-carbamic acid tert-butyl ester

Refernces

• 1、 Chan, Kelvin S. L.,Fu, Hai-Yan,Yu, Jin-Quan. "Palladium(II)-Catalyzed highly enantioselective C-H arylation of cyclopropylmethylamines". supporting information. p. 2042 - 2046. Retrieved 2015/03/04.
• 2、 -. "HETEROCYCLIC COMPOUNDS CONTAINING AN INDOLE CORE". Page/Page column 76. . Retrieved 2011/06/26.