3,4-Pyridinedicarboxylic acid dimethyl ester

Base Information

• Chemical Name: 3,4-Pyridinedicarboxylic acid dimethyl ester
• CAS No.: 1796-83-4
• Molecular Formula: C9H9NO4
• Molecular Weight: 195.175
• Hs Code.: 2933399090
• Mol file: 1796-83-4.mol

Synonyms:3,4-Pyridinedicarboxylicacid, dimethyl ester (6CI,7CI,8CI,9CI);Cinchomeronic acid, dimethyl ester;Dimethyl 3,4-pyridinedicarboxylate;

Chemical Property of 3,4-Pyridinedicarboxylic acid dimethyl ester

Chemical Property:

• Boiling Point: 244.7 °C at 760 mmHg
• PKA: 1.08±0.18(Predicted)
• Flash Point: 101.8 °C
• PSA: 65.49000
• Density: 1.231 g/cm³
• LogP: 0.65480
• Storage Temp.: 2-8°C

Purity/Quality:

98% purity ^*data from raw suppliers

3,4-dimethylpyridine-3,4-dicarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-Pyridinedicarboxylic acid dimethyl ester

There total 7 articles about 3,4-Pyridinedicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.8%

methanol (67-56-1) + 3,4-pyridinecarboxylic acid (490-11-9) → dimethyl 3,4-pyridinedicarboxylate (1796-83-4)

Guidance literature:

With thionyl chloride; for 3h; Reflux;

Reference yield: 72.0%

3,4-pyridinecarboxylic acid (490-11-9) + 2,2-dimethoxy-propane (77-76-9) → dimethyl 3,4-pyridinedicarboxylate (1796-83-4)

Guidance literature:

With thionyl chloride; In methanol; for 24h; Heating;

DOI:10.3987/com-97-s77

Reference yield: 68.0%

3,4-pyridinecarboxylic acid (490-11-9) → dimethyl 3,4-pyridinedicarboxylate (1796-83-4)

Guidance literature:

With sulfuric acid; In methanol; for 20h; Reflux;

DOI:10.1021/jacs.5b01036

upstream raw materials:

methanol

3,4-pyridinecarboxylic acid

4-(methoxycarbonyl)nicotinic acid

2,2-dimethoxy-propane

Downstream raw materials:

pyridine-3,4-dicarboxylic acid 3-methyl ester

4-(methoxycarbonyl)nicotinic acid

pyridine-3,4-diyldimethanol hydrochloride

4-chloro-2-[(2,4-dimethoxyphenyl)methyl]-1H,2H,3H-pyrrolo[3.4-c]pyridine

Refernces

• 1、 -. "NON-PEPTIDE OPIOID RECEPTOR MODULATORS". Page/Page column 15. . Retrieved 2020/03/15.
• 2、 Zheng, Yi,Obeng, Samuel,Wang, Huiqun,Jali, Abdulmajeed M.,Peddibhotla, Bharath,Williams, Dwight A.,Zou, Chuanchun,Stevens, David L.,Dewey, William L.,Akbarali, Hamid I.,Selley, Dana E.,Zhang, Yan. "Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands". supporting information. p. 561 - 574. Retrieved 2019/01/30.