3-phenylazetidine

Base Information

• Chemical Name: 3-phenylazetidine
• CAS No.: 4363-13-7
• Molecular Formula: C9H11N
• Molecular Weight: 133.193
• Hs Code.: 2933990090
• Mol file: 4363-13-7.mol

Synonyms:3-Phenylazetidine;

Chemical Property of 3-phenylazetidine

Chemical Property:

• Boiling Point: 226.8 °C at 760 mmHg
• PKA: 10.63±0.40(Predicted)
• Flash Point: 93.5 °C
• PSA: 12.03000
• Density: 1.015 g/cm³
• LogP: 1.70220
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

95% purity ^*data from raw suppliers

3-Phenylazetidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3-Phenylazetidine is a 3-substituted azetidine which shows analgesics and sympathomimetics effects.

Technology Process of 3-phenylazetidine

There total 3 articles about 3-phenylazetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

1-(diphenylmethyl)-3-phenylazetidine (913814-30-9) → phenyl-3-azetidine (4363-13-7)

Guidance literature:

With hydrogen; palladium(II) hydroxide/carbon; In ethanol; at 20 ℃; for 20.25h; under 3000.3 Torr;

Reference yield: 19.0%

→ phenyl-3-azetidine (4363-13-7)

Guidance literature:

Reference yield:

tert-butyl 3-phenylazetidine-1-carboxylate → phenyl-3-azetidine (4363-13-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 0 - 20 ℃; for 1h;

DOI:10.1021/jacs.5b03083

upstream raw materials:

1-(diphenylmethyl)-3-phenylazetidine

Downstream raw materials:

7-Chloro-6-(3-phenylazetidin-1-yl)-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine

(3-phenylazetidin-1-yl)(3,4,5-trimethoxyphenyl)methanone

C₁₈H₁₈N₄OS

(E)-6-(3-oxo-3-(3-phenylazetidin-1-yl)prop-1-en-1-yl)-3,4-dihydro-1,8-naphthyridin-2(1H)-one

Refernces

• 1、 Wang, Zhaobin,Sheong, Fu Kit,Sung, Herman H. Y.,Williams, Ian D.,Lin, Zhenyang,Sun, Jianwei. "Catalytic Enantioselective Intermolecular Desymmetrization of Azetidines". supporting information. p. 5895 - 5898. Retrieved 2015/05/27.
• 2、 -. "6-N-Linked Heterocycle-Substituted 2,3,4,5-Tetrahydro-1H-Benzo[d]Azepines as 5-Ht2c Receptor Agonists". Page/Page column 21. . Retrieved 2008/12/08.