3,4-DIPHENYLPYRIDINE

Base Information

• Chemical Name: 3,4-DIPHENYLPYRIDINE
• CAS No.: 5216-04-6
• Molecular Formula: C17H13N
• Molecular Weight: 231.297
• Hs Code.: 2933399090
• Mol file: 5216-04-6.mol

Synonyms:3,4-diphenylpyridine;

Chemical Property of 3,4-DIPHENYLPYRIDINE

Chemical Property:

• Vapor Pressure: 0.000124mmHg at 25°C
• Refractive Index: 1.605
• Boiling Point: 345.3 °C at 760 mmHg
• Flash Point: 147.4 °C
• PSA: 12.89000
• Density: 1.084 g/cm³
• LogP: 4.41560

Purity/Quality:

99% ^*data from raw suppliers

3,4-DIPHENYLPYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-DIPHENYLPYRIDINE

There total 19 articles about 3,4-DIPHENYLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(1R*,5R*)-5-azido-2,3-diphenylcyclopent-2-enol → 3,4-diphenylpyridine (5216-04-6)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,2-dichloro-ethane; at 80 ℃; for 5h; Inert atmosphere;

DOI:10.1021/ja9049564

Reference yield: 79.2%

2-chloro-4,5-diphenylpyridine (110567-95-8) → 3,4-diphenylpyridine (5216-04-6)

Guidance literature:

With potassium hydroxide; hydrogen; palladium on activated charcoal; In methanol; for 16h; Ambient temperature;

DOI:10.1021/jo00232a033

Reference yield: 79.0%

(E)-N-cinnamyl-N-tert-butoxycarbonyl-phenylethynylamine → 3,4-diphenylpyridine (5216-04-6)

Guidance literature:

(E)-N-cinnamyl-N-tert-butoxycarbonyl-phenylethynylamine; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; cyclohexane; at -78 ℃; for 1h; Inert atmosphere;

With o-tetrachloroquinone; acetic acid; In tetrahydrofuran; cyclohexane; at -78 - 20 ℃; chemoselective reaction; Inert atmosphere;

DOI:10.1021/ja303002a

upstream raw materials:

2-chloro-4,5-diphenylpyridine

1-(4-methylphenylsulfonyl)-4,5-diphenyl-1,2,5,6-tetrahydropyridine

4,5-diphenyl-2-pyridone

2,7-diphenyl-5-oxo-2,3,4,5-tetrahydro-1,4-thiazepine

Refernces

• 1、 Lui, Erica K. J.,Hergesell, Daniel,Schafer, Laurel L.. "N-Silylenamines as Reactive Intermediates: Hydroamination for the Modular Synthesis of Selectively Substituted Pyridines". supporting information. p. 6663 - 6667. Retrieved 2018/11/21.
• 2、 Gati, Wafa,Rammah, Mohamed M.,Rammah, Mohamed B.,Evano, Gwilherm. "Intramolecular carbolithiation of N-allyl-ynamides: An efficient entry to 1,4-dihydropyridines and pyridines - Application to a formal synthesis of sarizotan". . p. 2214 - 2222. Retrieved 2013/02/23.