5-CHLOROTRYPTOPHOL

Base Information

• Chemical Name: 5-CHLOROTRYPTOPHOL
• CAS No.: 61220-51-7
• Molecular Formula: C10H10ClNO
• Molecular Weight: 195.65
• Hs Code.: 2933990090
• Mol file: 61220-51-7.mol

Synonyms:Tryptophol,5-chloro- (6CI);5-Chlorotryptophol;2-(5-chloro-1H-indol-3-yl)ethanol;

Chemical Property of 5-CHLOROTRYPTOPHOL

Chemical Property:

• Boiling Point: 390.7 °C at 760 mmHg
• Flash Point: 190.1 °C
• PSA: 36.02000
• Density: 1.357 g/cm³
• LogP: 2.35610
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

5-Chlorotryptophol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-CHLOROTRYPTOPHOL

There total 9 articles about 5-CHLOROTRYPTOPHOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C11H12ClNO → 2-(5-chloro-1H-indol-3-yl)ethanol (61220-51-7)

Guidance literature:

In tetrahydrofuran; toluene; at 0 - 80 ℃; for 2h;

DOI:10.1021/acs.joc.1c01116

Reference yield: 86.0%

(5-chloro-1H-indol-3-yl)oxoacetic acid methylester (163160-55-2) → 2-(5-chloro-1H-indol-3-yl)ethanol (61220-51-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 0 - 70 ℃; for 5h;

DOI:10.1021/jm061131z

Reference yield: 42.3%

2-ethoxytetrahydrofuran (13436-46-9) + 4-chlorophenylhydrazine hydrochloride (1073-70-7) → 2-(5-chloro-1H-indol-3-yl)ethanol (61220-51-7)

Guidance literature:

In ethanol; Heating;

DOI:10.3987/COM-02-9703

upstream raw materials:

2-ethoxytetrahydrofuran

4-chlorophenylhydrazine hydrochloride

(5-chloro-1H-indol-3-yl)-oxo-acetic acid ethyl ester

(5-chloro-1H-indol-3-yl)oxoacetic acid methylester

Downstream raw materials:

5-chloro-3-(2-(4-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methyl)piperazin-1-yl)ethyl)-1H-indole

tert-butyl 5-chloro-3-(2-hydroxyethyl)-1H-indole-1-carboxylate

2-(5-chloro-1-methyl-1H-indol-3-yl)-ethanol

methyl 4-[2-[5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy]benzoate

Refernces

• 1、 Trost, Barry M.,Bai, Wen-Ju,Hohn, Christoph,Bai, Yu,Cregg, James J.. "Palladium-Catalyzed Asymmetric Allylic Alkylation of 3-Substituted 1 H-Indoles and Tryptophan Derivatives with Vinylcyclopropanes". supporting information. p. 6710 - 6717. Retrieved 2018/05/24.
• 2、 Liu, Xin,Wang, Songlin,Chen, Yin,Liu, Xinghua,Xu, Xiangqing,Liu, Bi-Feng,Zhang, Guisen. "Synthesis and evaluation of novel 2,3-dihydrobenzo[b][1,4]dioxin- and indolealkylamine derivatives as potential antidepressants". . p. 32 - 41. Retrieved 2014/01/23.