3-Bromo-5-chlorophenol

Base Information

• Chemical Name: 3-Bromo-5-chlorophenol
• CAS No.: 56962-04-0
• Molecular Formula: C6H4BrClO
• Molecular Weight: 207.454
• Hs Code.: 2908199090
• Mol file: 56962-04-0.mol

Synonyms:Phenol, 3-bromo-5-chloro-;3-bromo-5-chloro-phenol;3-Brom-5-chlor-phenol;2-AMINO-5-(2-PYRIDYL)-1,3,4-OXADIAZOLE;

Chemical Property of 3-Bromo-5-chlorophenol

Chemical Property:

• Vapor Pressure: 0.009mmHg at 25°C
• Melting Point: 66-70℃
• Refractive Index: 1.5730 (estimate)
• Boiling Point: 258.397oC at 760 mmHg
• PKA: 8.04±0.10(Predicted)
• Flash Point: 110.075oC
• PSA: 20.23000
• Density: 1.788g/cm3
• LogP: 2.80810
• Storage Temp.: Refrigerated.

Purity/Quality:

99% ^*data from raw suppliers

3-Bromo-5-chlorophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromo-5-chlorophenol

There total 9 articles about 3-Bromo-5-chlorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-bromo-3-chloro-5-methoxybenzene (174913-12-3) → 3-bromo-5-chlorophenol (56962-04-0)

Guidance literature:

1-bromo-3-chloro-5-methoxybenzene; With lithium iodide; In 2,4,6-trimethyl-pyridine; at 170 ℃; for 4h;

With hydrogenchloride; In 2,4,6-trimethyl-pyridine; water; at 20 ℃;

Reference yield: 81.0%

3-chloro-5-(4-methoxybenzyloxy)bromobenzene (210992-77-1) → 3-bromo-5-chlorophenol (56962-04-0)

Guidance literature:

With methanesulfonic acid; 1,3-Dimethoxybenzene; In toluene; at 10 ℃;

DOI:10.1021/op900322u

Reference yield: 81.0%

1-bromo-3-chlorobenzene (108-37-2) → 3-bromo-5-chlorophenol (56962-04-0)

Guidance literature:

1-bromo-3-chlorobenzene; With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; bis(pinacol)diborane; 4,4'-di-tert-butyl-2,2'-bipyridine; In hexane; at 20 ℃; for 18h; Inert atmosphere;

With Oxone; In water; acetone; for 0.166667h;

upstream raw materials:

3-chloro-2,4,5,6-tetrabromophenol

3-amino-5-chlorophenol

aluminium trichloride

benzene

Downstream raw materials:

3,4-dibromo-5-chloro-phenol

3-bromo-2,4,5,6-tetrachloro-phenol

3-bromo-5-chloro-2,4,6-triiodo-phenol

4-(3-bromo-5-chloro-phenoxy)-6-methoxy-5-nitro-nicotinic acid ethyl ester

Refernces

• 1、 -. "KINASE INHIBITORS". Page/Page column 217. . Retrieved 2015/01/06.
• 2、 Davidson, James P.,Sarma, Keshab,Fishlock, Dan,Welch, Michael H.,Sukhtankar, Sunil,Lee, Gary M.,Martin, Michael,Cooper, Gary F.. "A synthesis of 3,5-disubstituted phenols". experimental part. p. 477 - 480. Retrieved 2011/04/22.