C₁₉H₁₈FNO

Base Information

• Chemical Name: C₁₉H₁₈FNO
• CAS No.: 1282061-23-7
• Molecular Formula: C₁₉H₁₈FNO
• Molecular Weight: 295.356
• Mol file: 1282061-23-7.mol

Synonyms:C₁₉H₁₈FNO

Chemical Property of C₁₉H₁₈FNO

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₁₈FNO

There total 5 articles about C₁₉H₁₈FNO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C10H8ClFO + 2-allyl-phenylamine (32704-22-6) → C19H18FNO (1282061-23-7)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 12h;

DOI:10.1021/ol2006083

Reference yield:

1,3-diethyl 2-[(4-fluorophenyl)methyl]propanedioate (59223-74-4) → C19H18FNO (1282061-23-7)

Guidance literature:

Multi-step reaction with 4 steps

1: water; potassium hydroxide / ethanol / 10 h / 20 °C

2: dimethyl amine / Reflux

3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C

4: pyridine / dichloromethane / 12 h / 0 - 20 °C

With pyridine; oxalyl dichloride; water; dimethyl amine; N,N-dimethyl-formamide; potassium hydroxide; In ethanol; dichloromethane;

DOI:10.1021/ol2006083

Reference yield:

2-(4-Fluoro-benzyl)-acrylic acid → C19H18FNO (1282061-23-7)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C

2: pyridine / dichloromethane / 12 h / 0 - 20 °C

With pyridine; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1021/ol2006083

upstream raw materials:

2-allyl-phenylamine

1,3-diethyl 2-[(4-fluorophenyl)methyl]propanedioate

4-Fluorobenzyl bromide

2-(4-fluorobenzyl)malonic acid

Refernces