2-(3-fluorophenyl)-1H-pyrrole

Base Information

• Chemical Name: 2-(3-fluorophenyl)-1H-pyrrole
• CAS No.: 1616603-14-5
• Molecular Formula: C₁₀H₈FN
• Molecular Weight: 161.179
• Mol file: 1616603-14-5.mol

Synonyms:2-(3-fluorophenyl)-1H-pyrrole

Chemical Property of 2-(3-fluorophenyl)-1H-pyrrole

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

2-(3-Fluorophenyl)-1H-pyrrole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-fluorophenyl)-1H-pyrrole

There total 6 articles about 2-(3-fluorophenyl)-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

C12H12FNO2 (1616603-23-6) → 2-(3-fluorophenyl)-1H-pyrrole (1616603-14-5)

Guidance literature:

With copper(I) bromide; In toluene; at 120 ℃; Inert atmosphere;

DOI:10.1039/c4cc03129f

Reference yield: 67.0%

pyrrole (109-97-7,30604-81-0) + 3-fluorobromobenzene (1073-06-9) → 2-(3-fluorophenyl)-1H-pyrrole (1616603-14-5)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); potassium acetate; In N,N-dimethyl acetamide; at 130 ℃; for 8h; Inert atmosphere;

DOI:10.1055/s-0036-1588780

Reference yield:

3-Fluorobenzaldehyde (456-48-4) → 2-(3-fluorophenyl)-1H-pyrrole (1616603-14-5)

Guidance literature:

Multi-step reaction with 5 steps

1: ammonium chloride; zinc / tetrahydrofuran; water / 0 °C

2: Jones reagent / diethyl ether / 0 - 20 °C

3: hydroxylamine hydrochloride; sodium acetate / water; ethanol / 20 °C

4: triethylamine / dichloromethane / 0 °C

5: copper(I) bromide / toluene / 120 °C / Inert atmosphere

With Jones reagent; hydroxylamine hydrochloride; sodium acetate; ammonium chloride; triethylamine; copper(I) bromide; zinc; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; toluene;

DOI:10.1039/c4cc03129f

upstream raw materials:

3-Fluorobenzaldehyde

(+/-)-1-(3'-fluorophenyl)but-3-en-1-ol

1-(3-fluoro-phenyl)-but-3-en-1-one

C₁₂H₁₂FNO₂

Refernces

• 1、 Du, Wei,Zhao, Mi-Na,Ren, Zhi-Hui,Wang, Yao-Yu,Guan, Zheng-Hui. "Copper-catalyzed 5-endo-trig cyclization of ketoxime carboxylates: A facile synthesis of 2-arylpyrroles". . p. 7437 - 7439. Retrieved 2014/07/07.